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The structural basis of transfer RNA mimicry and conformational plasticity by a viral RNA

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Listed:
  • Timothy M. Colussi

    (University of Colorado Denver School of Medicine
    Howard Hughes Medical Institute, University of Colorado Denver School of Medicine
    Present addresses: Department of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts 02115, USA (T.M.C.); Department of Integrative Structural and Computational Biology, Scripps Research Institute, La Jolla, California 92037, USA (J.A.H.).)

  • David A. Costantino

    (University of Colorado Denver School of Medicine
    Howard Hughes Medical Institute, University of Colorado Denver School of Medicine)

  • John A. Hammond

    (University of Colorado Denver School of Medicine
    Present addresses: Department of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts 02115, USA (T.M.C.); Department of Integrative Structural and Computational Biology, Scripps Research Institute, La Jolla, California 92037, USA (J.A.H.).)

  • Grant M. Ruehle

    (University of Colorado Denver School of Medicine)

  • Jay C. Nix

    (Molecular Biology Consortium, Advanced Light Source, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA)

  • Jeffrey S. Kieft

    (University of Colorado Denver School of Medicine
    Howard Hughes Medical Institute, University of Colorado Denver School of Medicine)

Abstract

RNA molecules can perform multiple functions, which can be driven by different conformational states; here, the crystal structure of the transfer-RNA-like structure of the turnip yellow mosaic virus is solved, providing insight into the structural basis of RNA multifunctionality.

Suggested Citation

  • Timothy M. Colussi & David A. Costantino & John A. Hammond & Grant M. Ruehle & Jay C. Nix & Jeffrey S. Kieft, 2014. "The structural basis of transfer RNA mimicry and conformational plasticity by a viral RNA," Nature, Nature, vol. 511(7509), pages 366-369, July.
    • Handle: RePEc:nat:nature:v:511:y:2014:i:7509:d:10.1038_nature13378
    DOI: 10.1038/nature13378
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