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SOX2 controls tumour initiation and cancer stem-cell functions in squamous-cell carcinoma

Author

Listed:
  • Soufiane Boumahdi

    (Université Libre de Bruxelles, IRIBHM, Brussels B-1070, Belgium)

  • Gregory Driessens

    (Université Libre de Bruxelles, IRIBHM, Brussels B-1070, Belgium)

  • Gaelle Lapouge

    (Université Libre de Bruxelles, IRIBHM, Brussels B-1070, Belgium)

  • Sandrine Rorive

    (Erasme Hospital, Université Libre de Bruxelles, Brussels B-1070, Belgium
    DIAPATH—Center for Microscopy and Molecular Imaging (CMMI), Gosselies B-6041, Belgium)

  • Dany Nassar

    (Université Libre de Bruxelles, IRIBHM, Brussels B-1070, Belgium)

  • Marie Le Mercier

    (Erasme Hospital, Université Libre de Bruxelles, Brussels B-1070, Belgium)

  • Benjamin Delatte

    (Laboratory of Cancer Epigenetics, Université Libre de Bruxelles, Brussels B-1070, Belgium)

  • Amélie Caauwe

    (Université Libre de Bruxelles, IRIBHM, Brussels B-1070, Belgium)

  • Sandrine Lenglez

    (Université Libre de Bruxelles, IRIBHM, Brussels B-1070, Belgium)

  • Erwin Nkusi

    (Université Libre de Bruxelles, IRIBHM, Brussels B-1070, Belgium)

  • Sylvain Brohée

    (Machine Learning Group, Faculté des Sciences, Université Libre de Bruxelles, Brussels B-1050, Belgium)

  • Isabelle Salmon

    (Erasme Hospital, Université Libre de Bruxelles, Brussels B-1070, Belgium
    DIAPATH—Center for Microscopy and Molecular Imaging (CMMI), Gosselies B-6041, Belgium)

  • Christine Dubois

    (Université Libre de Bruxelles, IRIBHM, Brussels B-1070, Belgium)

  • Veronique del Marmol

    (Erasme Hospital, Université Libre de Bruxelles, Brussels B-1070, Belgium)

  • Francois Fuks

    (Laboratory of Cancer Epigenetics, Université Libre de Bruxelles, Brussels B-1070, Belgium)

  • Benjamin Beck

    (Université Libre de Bruxelles, IRIBHM, Brussels B-1070, Belgium)

  • Cédric Blanpain

    (Université Libre de Bruxelles, IRIBHM, Brussels B-1070, Belgium
    WELBIO, Université Libre de Bruxelles, Brussels B-1070, Belgium)

Abstract

Here, in a mouse model of skin squamous cell carcinoma, a key role is demonstrated for the transcription factor SOX2 in the initiation and progression of skin tumours.

Suggested Citation

  • Soufiane Boumahdi & Gregory Driessens & Gaelle Lapouge & Sandrine Rorive & Dany Nassar & Marie Le Mercier & Benjamin Delatte & Amélie Caauwe & Sandrine Lenglez & Erwin Nkusi & Sylvain Brohée & Isabell, 2014. "SOX2 controls tumour initiation and cancer stem-cell functions in squamous-cell carcinoma," Nature, Nature, vol. 511(7508), pages 246-250, July.
    • Handle: RePEc:nat:nature:v:511:y:2014:i:7508:d:10.1038_nature13305
    DOI: 10.1038/nature13305
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    Cited by:

    1. Yang Gu & Zhibin Yi & Ziheng Zhou & Jianyi Wang & Shan Li & Pingping Zhu & Nian Liu & Yuwei Xu & Lei He & Yanying Wang & Zusen Fan, 2024. "SNORD88B-mediated WRN nucleolar trafficking drives self-renewal in liver cancer initiating cells and hepatocarcinogenesis," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    2. Mingsen Li & Huaxing Huang & Bofeng Wang & Shaoshuai Jiang & Huizhen Guo & Liqiong Zhu & Siqi Wu & Jiafeng Liu & Li Wang & Xihong Lan & Wang Zhang & Jin Zhu & Fuxi Li & Jieying Tan & Zhen Mao & Chunqi, 2022. "Comprehensive 3D epigenomic maps define limbal stem/progenitor cell function and identity," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    3. Hui Yang & Qingqing Li & Xingxing Chen & Mingzhe Weng & Yakai Huang & Qiwen Chen & Xiaocen Liu & Haoyu Huang & Yanhuizhi Feng & Hanyu Zhou & Mengying Zhang & Weiya Pei & Xueqin Li & Qingsheng Fu & Lia, 2024. "Targeting SOX13 inhibits assembly of respiratory chain supercomplexes to overcome ferroptosis resistance in gastric cancer," Nature Communications, Nature, vol. 15(1), pages 1-21, December.

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