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Structural basis for lipopolysaccharide insertion in the bacterial outer membrane

Author

Listed:
  • Shuai Qiao

    (National Laboratory of Biomacromolecules, National Center of Protein Science-Beijing, Institute of Biophysics, Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Qingshan Luo

    (National Laboratory of Biomacromolecules, National Center of Protein Science-Beijing, Institute of Biophysics, Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Yan Zhao

    (National Laboratory of Biomacromolecules, National Center of Protein Science-Beijing, Institute of Biophysics, Chinese Academy of Sciences
    School of Life Sciences, University of Science and Technology of China, Hefei 230027, Anhui, China)

  • Xuejun Cai Zhang

    (National Laboratory of Biomacromolecules, National Center of Protein Science-Beijing, Institute of Biophysics, Chinese Academy of Sciences)

  • Yihua Huang

    (National Laboratory of Biomacromolecules, National Center of Protein Science-Beijing, Institute of Biophysics, Chinese Academy of Sciences)

Abstract

Lipopolysaccharide, an essential component of the Gram-negative bacteria outer membrane, is inserted by LptD–LptE, a protein complex with a unique ‘barrel and plug’ architecture; the structure of the LptD–LptE complex of Shigella flexneri determined here shows LptD forming a 26-stranded β-barrel with LptE located inside the barrel of LptD, the first two β-strands are distorted by two proline residues, creating a potential portal in the barrel wall that might allow lateral diffusion of lipopolysaccharide into the outer membrane.

Suggested Citation

  • Shuai Qiao & Qingshan Luo & Yan Zhao & Xuejun Cai Zhang & Yihua Huang, 2014. "Structural basis for lipopolysaccharide insertion in the bacterial outer membrane," Nature, Nature, vol. 511(7507), pages 108-111, July.
    • Handle: RePEc:nat:nature:v:511:y:2014:i:7507:d:10.1038_nature13484
    DOI: 10.1038/nature13484
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    Cited by:

    1. Yiying Yang & Haoxiang Chen & Robin A. Corey & Violette Morales & Yves Quentin & Carine Froment & Anne Caumont-Sarcos & Cécile Albenne & Odile Burlet-Schiltz & David Ranava & Phillip J. Stansfeld & Ju, 2023. "LptM promotes oxidative maturation of the lipopolysaccharide translocon by substrate binding mimicry," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    2. Mathieu Botte & Dongchun Ni & Stephan Schenck & Iwan Zimmermann & Mohamed Chami & Nicolas Bocquet & Pascal Egloff & Denis Bucher & Matilde Trabuco & Robert K. Y. Cheng & Janine D. Brunner & Markus A. , 2022. "Cryo-EM structures of a LptDE transporter in complex with Pro-macrobodies offer insight into lipopolysaccharide translocation," Nature Communications, Nature, vol. 13(1), pages 1-10, December.

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