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Anti-diabetic activity of insulin-degrading enzyme inhibitors mediated by multiple hormones

Author

Listed:
  • Juan Pablo Maianti

    (Harvard University)

  • Amanda McFedries

    (Harvard University)

  • Zachariah H. Foda

    (Stony Brook University)

  • Ralph E. Kleiner

    (Harvard University)

  • Xiu Quan Du

    (Albert Einstein College of Medicine)

  • Malcolm A. Leissring

    (Institute for Memory Impairments and Neurological Disorders, University of California)

  • Wei-Jen Tang

    (University of Chicago)

  • Maureen J. Charron

    (Albert Einstein College of Medicine)

  • Markus A. Seeliger

    (Stony Brook University)

  • Alan Saghatelian

    (Harvard University)

  • David R. Liu

    (Harvard University
    Howard Hughes Medical Institute, Harvard University)

Abstract

The discovery of a selective, physiologically active inhibitor of insulin-degrading enzyme (IDE) illuminates the therapeutic potential of IDE inhibitors for the treatment of diabetes and reveals that IDE regulates in vivo glucagon and amylin, in addition to insulin.

Suggested Citation

  • Juan Pablo Maianti & Amanda McFedries & Zachariah H. Foda & Ralph E. Kleiner & Xiu Quan Du & Malcolm A. Leissring & Wei-Jen Tang & Maureen J. Charron & Markus A. Seeliger & Alan Saghatelian & David R., 2014. "Anti-diabetic activity of insulin-degrading enzyme inhibitors mediated by multiple hormones," Nature, Nature, vol. 511(7507), pages 94-98, July.
    • Handle: RePEc:nat:nature:v:511:y:2014:i:7507:d:10.1038_nature13297
    DOI: 10.1038/nature13297
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    Cited by:

    1. Wenguang G. Liang & Juwina Wijaya & Hui Wei & Alex J. Noble & Jordan M. Mancl & Swansea Mo & David Lee & John V. Lin King & Man Pan & Chang Liu & Carla M. Koehler & Minglei Zhao & Clinton S. Potter & , 2022. "Structural basis for the mechanisms of human presequence protease conformational switch and substrate recognition," Nature Communications, Nature, vol. 13(1), pages 1-14, December.

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