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RLIM is dispensable for X-chromosome inactivation in the mouse embryonic epiblast

Author

Listed:
  • JongDae Shin

    (Program in Gene Function and Expression, University of Massachusetts Medical School (UMMS))

  • Mary C. Wallingford

    (Veterinary & Animal Sciences, University of Massachusetts Amherst)

  • Judith Gallant

    (UMMS)

  • Chelsea Marcho

    (Veterinary & Animal Sciences, University of Massachusetts Amherst)

  • Baowei Jiao

    (Program in Gene Function and Expression, University of Massachusetts Medical School (UMMS)
    Present address: Kunming Institute of Zoology, Chinese Academy of Science, Kunming 650223, China.)

  • Meg Byron

    (UMMS)

  • Michael Bossenz

    (Ortenau Klinikum Lahr-Ettenheim, Institut für Pathologie, 77933 Lahr, Germany)

  • Jeanne B. Lawrence

    (UMMS)

  • Stephen N. Jones

    (UMMS)

  • Jesse Mager

    (Veterinary & Animal Sciences, University of Massachusetts Amherst)

  • Ingolf Bach

    (Program in Gene Function and Expression, University of Massachusetts Medical School (UMMS)
    Program in Molecular Medicine, UMMS)

Abstract

The ubiquitin ligase RLIM is known to activate the long non-coding RNA Xist, which is crucial for X-chromosome inactivation in female mice; however, unlike imprinted X-chromosome inactivation that requires RLIM for Xist expression, evidence is now provided that during random X-chromosome inactivation Xist expression is regulated by an RLIM-independent pathway in vivo.

Suggested Citation

  • JongDae Shin & Mary C. Wallingford & Judith Gallant & Chelsea Marcho & Baowei Jiao & Meg Byron & Michael Bossenz & Jeanne B. Lawrence & Stephen N. Jones & Jesse Mager & Ingolf Bach, 2014. "RLIM is dispensable for X-chromosome inactivation in the mouse embryonic epiblast," Nature, Nature, vol. 511(7507), pages 86-89, July.
    • Handle: RePEc:nat:nature:v:511:y:2014:i:7507:d:10.1038_nature13286
    DOI: 10.1038/nature13286
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    Cited by:

    1. Milan Kumar Samanta & Srimonta Gayen & Clair Harris & Emily Maclary & Yumie Murata-Nakamura & Rebecca M. Malcore & Robert S. Porter & Patricia M. Garay & Christina N. Vallianatos & Paul B. Samollow & , 2022. "Activation of Xist by an evolutionarily conserved function of KDM5C demethylase," Nature Communications, Nature, vol. 13(1), pages 1-16, December.

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