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Analysis of orthologous groups reveals archease and DDX1 as tRNA splicing factors

Author

Listed:
  • Johannes Popow

    (Institute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA)
    European Molecular Biology Laboratory (EMBL))

  • Jennifer Jurkin

    (Institute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA))

  • Alexander Schleiffer

    (IMP/IMBA Bioinformatics Core Facility, Research Institute of Molecular Pathology (IMP))

  • Javier Martinez

    (Institute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA))

Abstract

Using a phylogenetic approach, the protein archease is identified as being a subunit of the human transfer RNA splicing ligase, and found to be necessary for full ligase activity, in cooperation with DDX1.

Suggested Citation

  • Johannes Popow & Jennifer Jurkin & Alexander Schleiffer & Javier Martinez, 2014. "Analysis of orthologous groups reveals archease and DDX1 as tRNA splicing factors," Nature, Nature, vol. 511(7507), pages 104-107, July.
    • Handle: RePEc:nat:nature:v:511:y:2014:i:7507:d:10.1038_nature13284
    DOI: 10.1038/nature13284
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    Cited by:

    1. Yangyang Li & Shichen Su & Yanqing Gao & Guoliang Lu & Hehua Liu & Xi Chen & Zhiwei Shao & Yixi Zhang & Qiyuan Shao & Xin Zhao & Jie Yang & Chulei Cao & Jinzhong Lin & Jinbiao Ma & Jianhua Gan, 2022. "Crystal structures and insights into precursor tRNA 5’-end processing by prokaryotic minimal protein-only RNase P," Nature Communications, Nature, vol. 13(1), pages 1-13, December.

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