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The sonic hedgehog factor GLI1 imparts drug resistance through inducible glucuronidation

Author

Listed:
  • Hiba Ahmad Zahreddine

    (Université de Montréal, P.O. Box 6128, Downtown Station, Montréal, Québec H3C 3J7, Canada)

  • Biljana Culjkovic-Kraljacic

    (Université de Montréal, P.O. Box 6128, Downtown Station, Montréal, Québec H3C 3J7, Canada)

  • Sarit Assouline

    (Segal Cancer Centre, Lady Davis Institute, Jewish General Hospital, McGill University, 3755 Côte-Ste-Catherine Road, Montréal, Québec H3T 1E2, Canada)

  • Patrick Gendron

    (Université de Montréal, P.O. Box 6128, Downtown Station, Montréal, Québec H3C 3J7, Canada)

  • Andrea A. Romeo

    (Pharmascience Inc., 6111 Royalmount Avenue, Montreal, Quebec H4P 2T4, Canada)

  • Stephen J. Morris

    (Pharmascience Inc., 6111 Royalmount Avenue, Montreal, Quebec H4P 2T4, Canada)

  • Gregory Cormack

    (Université de Montréal, P.O. Box 6128, Downtown Station, Montréal, Québec H3C 3J7, Canada)

  • James B. Jaquith

    (Pharmascience Inc., 6111 Royalmount Avenue, Montreal, Quebec H4P 2T4, Canada
    Present address: JAQJAM Consulting, Montreal J7V 9B6, Canada.)

  • Leandro Cerchietti

    (Weill Cornell Medical College, Cornell University, 1305 York Avenue, New York, New York 10021, USA)

  • Eftihia Cocolakis

    (Segal Cancer Centre, Lady Davis Institute, Jewish General Hospital, McGill University, 3755 Côte-Ste-Catherine Road, Montréal, Québec H3T 1E2, Canada)

  • Abdellatif Amri

    (Université de Montréal, P.O. Box 6128, Downtown Station, Montréal, Québec H3C 3J7, Canada)

  • Julie Bergeron

    (Hôpital Maisonneuve-Rosemont, 5415 Boulevard de l’Assomption, Montréal, Québec H1T 2M4, Canada)

  • Brian Leber

    (McMaster University/Hamilton Health Sciences, 237 Barton Street East, Hamilton, Ontario L8L 2X2, Canada)

  • Michael W. Becker

    (601 Elmwood Avenue, University of Rochester)

  • Shanshan Pei

    (University of Colorado Denver, 13123 East 16th Avenue, Aurora, Colorado 80045, USA)

  • Craig T. Jordan

    (University of Colorado Denver, 13123 East 16th Avenue, Aurora, Colorado 80045, USA)

  • Wilson H. Miller

    (Segal Cancer Centre, Lady Davis Institute, Jewish General Hospital, McGill University, 3755 Côte-Ste-Catherine Road, Montréal, Québec H3T 1E2, Canada)

  • Katherine L. B. Borden

    (Université de Montréal, P.O. Box 6128, Downtown Station, Montréal, Québec H3C 3J7, Canada)

Abstract

A new mechanism by which acute myeloid leukaemia patients become resistant to Ara-C and a newer treatment, ribavirin, is uncovered; these drugs can be glucuronidated and thereby inactivated by members of the UDP glucuronosyltransferase family of enzymes activated through GLI1 signalling.

Suggested Citation

  • Hiba Ahmad Zahreddine & Biljana Culjkovic-Kraljacic & Sarit Assouline & Patrick Gendron & Andrea A. Romeo & Stephen J. Morris & Gregory Cormack & James B. Jaquith & Leandro Cerchietti & Eftihia Cocola, 2014. "The sonic hedgehog factor GLI1 imparts drug resistance through inducible glucuronidation," Nature, Nature, vol. 511(7507), pages 90-93, July.
    • Handle: RePEc:nat:nature:v:511:y:2014:i:7507:d:10.1038_nature13283
    DOI: 10.1038/nature13283
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