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BRCA1 controls homologous recombination at Tus/Ter-stalled mammalian replication forks

Author

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  • Nicholas A. Willis

    (Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue)

  • Gurushankar Chandramouly

    (Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue
    Present addresses: Temple University, 1801 North Broad Street, Philadelphia, Pennsylvania 19122, USA (G.C.); Brandeis University, 415 South Street, Waltham, Massachusetts 02453, USA (B.H.); University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, Massachusetts 01655, USA (A.K.).)

  • Bin Huang

    (Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue
    Present addresses: Temple University, 1801 North Broad Street, Philadelphia, Pennsylvania 19122, USA (G.C.); Brandeis University, 415 South Street, Waltham, Massachusetts 02453, USA (B.H.); University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, Massachusetts 01655, USA (A.K.).)

  • Amy Kwok

    (Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue
    Present addresses: Temple University, 1801 North Broad Street, Philadelphia, Pennsylvania 19122, USA (G.C.); Brandeis University, 415 South Street, Waltham, Massachusetts 02453, USA (B.H.); University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, Massachusetts 01655, USA (A.K.).)

  • Cindy Follonier

    (Princeton University, 101 Lewis Thomas Laboratory, Washington Road, Princeton, New Jersey 08544, USA)

  • Chuxia Deng

    (NIDDK, National Institutes of Health, Building 10, Room 9N105, 10 Center Drive)

  • Ralph Scully

    (Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue)

Abstract

Direct evidence for the role of BRCA1 in controlling homologous recombination at stalled replication forks has been obtained in mammalian cells using the bacterial Tus/Ter system.

Suggested Citation

  • Nicholas A. Willis & Gurushankar Chandramouly & Bin Huang & Amy Kwok & Cindy Follonier & Chuxia Deng & Ralph Scully, 2014. "BRCA1 controls homologous recombination at Tus/Ter-stalled mammalian replication forks," Nature, Nature, vol. 510(7506), pages 556-559, June.
    • Handle: RePEc:nat:nature:v:510:y:2014:i:7506:d:10.1038_nature13295
    DOI: 10.1038/nature13295
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    Cited by:

    1. Nagham Ghaddar & Yves Corda & Pierre Luciano & Martina Galli & Ylli Doksani & Vincent Géli, 2023. "The COMPASS subunit Spp1 protects nascent DNA at the Tus/Ter replication fork barrier by limiting DNA availability to nucleases," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    2. Yi-Li Feng & Qian Liu & Ruo-Dan Chen & Si-Cheng Liu & Zhi-Cheng Huang & Kun-Ming Liu & Xiao-Ying Yang & An-Yong Xie, 2022. "DNA nicks induce mutational signatures associated with BRCA1 deficiency," Nature Communications, Nature, vol. 13(1), pages 1-15, December.

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