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Human oocytes reprogram adult somatic nuclei of a type 1 diabetic to diploid pluripotent stem cells

Author

Listed:
  • Mitsutoshi Yamada

    (The New York Stem Cell Foundation Research Institute)

  • Bjarki Johannesson

    (The New York Stem Cell Foundation Research Institute)

  • Ido Sagi

    (Stem Cell Unit, Silberman Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem 91904, Israel)

  • Lisa Cole Burnett

    (Naomi Berrie Diabetes Center, College of Physicians and Surgeons, Columbia University)

  • Daniel H. Kort

    (Center for Women’s Reproductive Care, College of Physicians and Surgeons, Columbia University
    College of Physicians and Surgeons, Columbia University)

  • Robert W. Prosser

    (Center for Women’s Reproductive Care, College of Physicians and Surgeons, Columbia University
    College of Physicians and Surgeons, Columbia University)

  • Daniel Paull

    (The New York Stem Cell Foundation Research Institute)

  • Michael W. Nestor

    (The New York Stem Cell Foundation Research Institute)

  • Matthew Freeby

    (Naomi Berrie Diabetes Center, College of Physicians and Surgeons, Columbia University)

  • Ellen Greenberg

    (Naomi Berrie Diabetes Center, College of Physicians and Surgeons, Columbia University)

  • Robin S. Goland

    (Naomi Berrie Diabetes Center, College of Physicians and Surgeons, Columbia University)

  • Rudolph L. Leibel

    (Naomi Berrie Diabetes Center, College of Physicians and Surgeons, Columbia University)

  • Susan L. Solomon

    (The New York Stem Cell Foundation Research Institute)

  • Nissim Benvenisty

    (Stem Cell Unit, Silberman Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem 91904, Israel)

  • Mark V. Sauer

    (Center for Women’s Reproductive Care, College of Physicians and Surgeons, Columbia University
    College of Physicians and Surgeons, Columbia University)

  • Dieter Egli

    (The New York Stem Cell Foundation Research Institute)

Abstract

Here human embryonic stem cell lines are derived by somatic cell nuclear transfer from cells of a newborn and from skin cells of an adult, a female with type 1 diabetes; the stem cells produced are pluripotent and can be differentiated into insulin-producing beta cells.

Suggested Citation

  • Mitsutoshi Yamada & Bjarki Johannesson & Ido Sagi & Lisa Cole Burnett & Daniel H. Kort & Robert W. Prosser & Daniel Paull & Michael W. Nestor & Matthew Freeby & Ellen Greenberg & Robin S. Goland & Rud, 2014. "Human oocytes reprogram adult somatic nuclei of a type 1 diabetic to diploid pluripotent stem cells," Nature, Nature, vol. 510(7506), pages 533-536, June.
    • Handle: RePEc:nat:nature:v:510:y:2014:i:7506:d:10.1038_nature13287
    DOI: 10.1038/nature13287
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    Cited by:

    1. Qiliang Ding & Matthew M. Edwards & Ning Wang & Xiang Zhu & Alexa N. Bracci & Michelle L. Hulke & Ya Hu & Yao Tong & Joyce Hsiao & Christine J. Charvet & Sulagna Ghosh & Robert E. Handsaker & Kevin Eg, 2021. "The genetic architecture of DNA replication timing in human pluripotent stem cells," Nature Communications, Nature, vol. 12(1), pages 1-18, December.

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