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Co-opting sulphur-carrier proteins from primary metabolic pathways for 2-thiosugar biosynthesis

Author

Listed:
  • Eita Sasaki

    (University of Texas at Austin)

  • Xuan Zhang

    (Cornell University)

  • He G. Sun

    (College of Pharmacy, University of Texas at Austin)

  • Mei-Yeh Jade Lu

    (Biodiversity Research Center, Academia Sinica, Taipei 115, Taiwan
    Genomics Research Center, Academia Sinica, Taipei 115, Taiwan)

  • Tsung-lin Liu

    (Genomics Research Center, Academia Sinica, Taipei 115, Taiwan
    Institute of Bioinformatics and Biosignal Transduction, National Cheng-Kung University, Tainan 701, Taiwan)

  • Albert Ou

    (Genomics Research Center, Academia Sinica, Taipei 115, Taiwan)

  • Jeng-yi Li

    (Biodiversity Research Center, Academia Sinica, Taipei 115, Taiwan)

  • Yu-hsiang Chen

    (Biodiversity Research Center, Academia Sinica, Taipei 115, Taiwan)

  • Steven E. Ealick

    (Cornell University)

  • Hung-wen Liu

    (University of Texas at Austin
    College of Pharmacy, University of Texas at Austin)

Abstract

How sulphur is incorporated into sulphur-containing secondary metabolites is poorly understood; here, the bacterium Amycolatopsis orientalis is shown to co-opt sulphur-carrier proteins from primary metabolic pathways to facilitate the biosynthesis of sulphur-containing natural products.

Suggested Citation

  • Eita Sasaki & Xuan Zhang & He G. Sun & Mei-Yeh Jade Lu & Tsung-lin Liu & Albert Ou & Jeng-yi Li & Yu-hsiang Chen & Steven E. Ealick & Hung-wen Liu, 2014. "Co-opting sulphur-carrier proteins from primary metabolic pathways for 2-thiosugar biosynthesis," Nature, Nature, vol. 510(7505), pages 427-431, June.
    • Handle: RePEc:nat:nature:v:510:y:2014:i:7505:d:10.1038_nature13256
    DOI: 10.1038/nature13256
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