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PTEN action in leukaemia dictated by the tissue microenvironment

Author

Listed:
  • Cornelius Miething

    (Memorial Sloan Kettering Cancer Center
    Cold Spring Harbor Laboratory
    Present address: Department of Medicine I, Medical Center – University of Freiburg, 79106 Freiburg, Germany.)

  • Claudio Scuoppo

    (Cold Spring Harbor Laboratory)

  • Benedikt Bosbach

    (Memorial Sloan Kettering Cancer Center)

  • Iris Appelmann

    (Memorial Sloan Kettering Cancer Center
    Cold Spring Harbor Laboratory)

  • Joy Nakitandwe

    (St. Jude Children’s Research Hospital)

  • Jing Ma

    (St. Jude Children’s Research Hospital)

  • Gang Wu

    (St. Jude Children’s Research Hospital)

  • Laura Lintault

    (Cold Spring Harbor Laboratory
    Howard Hughes Medical Institute)

  • Martina Auer

    (Institute of Human Genetics, Medical University of Graz, A-8010 Graz, Austria)

  • Prem K. Premsrirut

    (Cold Spring Harbor Laboratory)

  • Julie Teruya-Feldstein

    (Memorial Sloan Kettering Cancer Center)

  • James Hicks

    (Cold Spring Harbor Laboratory)

  • Helene Benveniste

    (Stony Brook University)

  • Michael R. Speicher

    (Institute of Human Genetics, Medical University of Graz, A-8010 Graz, Austria)

  • James R. Downing

    (St. Jude Children’s Research Hospital)

  • Scott W. Lowe

    (Memorial Sloan Kettering Cancer Center
    Cold Spring Harbor Laboratory
    Howard Hughes Medical Institute)

Abstract

A mouse model of T-cell leukaemia is used to test whether PTEN loss is required for tumour maintenance as well as initiation; although it had little effect on tumour load in haematopoietic organs, PTEN reactivation reduced the CCR9-dependent tumour dissemination to the intestine that was amplified on PTEN loss, exposing the importance of tumour microenvironment in PTEN-deficient settings.

Suggested Citation

  • Cornelius Miething & Claudio Scuoppo & Benedikt Bosbach & Iris Appelmann & Joy Nakitandwe & Jing Ma & Gang Wu & Laura Lintault & Martina Auer & Prem K. Premsrirut & Julie Teruya-Feldstein & James Hick, 2014. "PTEN action in leukaemia dictated by the tissue microenvironment," Nature, Nature, vol. 510(7505), pages 402-406, June.
    • Handle: RePEc:nat:nature:v:510:y:2014:i:7505:d:10.1038_nature13239
    DOI: 10.1038/nature13239
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    Cited by:

    1. Christopher W. Murray & Jennifer J. Brady & Mingqi Han & Hongchen Cai & Min K. Tsai & Sarah E. Pierce & Ran Cheng & Janos Demeter & David M. Feldser & Peter K. Jackson & David B. Shackelford & Monte M, 2022. "LKB1 drives stasis and C/EBP-mediated reprogramming to an alveolar type II fate in lung cancer," Nature Communications, Nature, vol. 13(1), pages 1-19, December.

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