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SMYD3 links lysine methylation of MAP3K2 to Ras-driven cancer

Author

Listed:
  • Pawel K. Mazur

    (Stanford University School of Medicine
    Stanford University School of Medicine)

  • Nicolas Reynoird

    (Stanford University)

  • Purvesh Khatri

    (Institute for Immunity, Transplantation and Infection, Stanford University School of Medicine)

  • Pascal W. T. C. Jansen

    (University Medical Center Utrecht, 3508 AB Utrecht, The Netherlands)

  • Alex W. Wilkinson

    (Stanford University)

  • Shichong Liu

    (Perelman School of Medicine, University of Pennsylvania)

  • Olena Barbash

    (Cancer Epigenetics DPU, Oncology R&D, GlaxoSmithKline, Collegeville)

  • Glenn S. Van Aller

    (Cancer Epigenetics DPU, Oncology R&D, GlaxoSmithKline, Collegeville)

  • Michael Huddleston

    (Cancer Epigenetics DPU, Oncology R&D, GlaxoSmithKline, Collegeville)

  • Dashyant Dhanak

    (Cancer Epigenetics DPU, Oncology R&D, GlaxoSmithKline, Collegeville
    Present addresses: Janssen Research and Development, 1400 McKean Road, Spring House, Pennsylvania 19477, USA (D.D.); Department of Molecular Biology, Faculty of Science, Radboud Institute for Molecular Life Sciences (RIMLS), Radboud University, 6525GA Nijmegen, The Netherlands (M.V.).)

  • Peter J. Tummino

    (Cancer Epigenetics DPU, Oncology R&D, GlaxoSmithKline, Collegeville)

  • Ryan G. Kruger

    (Cancer Epigenetics DPU, Oncology R&D, GlaxoSmithKline, Collegeville)

  • Benjamin A. Garcia

    (Perelman School of Medicine, University of Pennsylvania)

  • Atul J. Butte

    (Stanford University School of Medicine
    Stanford University School of Medicine)

  • Michiel Vermeulen

    (University Medical Center Utrecht, 3508 AB Utrecht, The Netherlands
    Present addresses: Janssen Research and Development, 1400 McKean Road, Spring House, Pennsylvania 19477, USA (D.D.); Department of Molecular Biology, Faculty of Science, Radboud Institute for Molecular Life Sciences (RIMLS), Radboud University, 6525GA Nijmegen, The Netherlands (M.V.).)

  • Julien Sage

    (Stanford University School of Medicine
    Stanford University School of Medicine)

  • Or Gozani

    (Stanford University)

Abstract

SMYD3 is a methyltransferase overexpressed in several human tumours; here methylation of the MAP3K2 kinase by SMYD3 is shown to be critical for Ras-induced tumour development in mouse models and human tumour cells, showing an unexpected role for methylation in a kinase signalling pathway and revealing a candidate therapeutic target.

Suggested Citation

  • Pawel K. Mazur & Nicolas Reynoird & Purvesh Khatri & Pascal W. T. C. Jansen & Alex W. Wilkinson & Shichong Liu & Olena Barbash & Glenn S. Van Aller & Michael Huddleston & Dashyant Dhanak & Peter J. Tu, 2014. "SMYD3 links lysine methylation of MAP3K2 to Ras-driven cancer," Nature, Nature, vol. 510(7504), pages 283-287, June.
    • Handle: RePEc:nat:nature:v:510:y:2014:i:7504:d:10.1038_nature13320
    DOI: 10.1038/nature13320
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    Cited by:

    1. Bo Yu & Jun Su & Qiqi Shi & Qing Liu & Jun Ma & Guoqing Ru & Lei Zhang & Jian Zhang & Xichun Hu & Jianming Tang, 2022. "KMT5A-methylated SNIP1 promotes triple-negative breast cancer metastasis by activating YAP signaling," Nature Communications, Nature, vol. 13(1), pages 1-18, December.
    2. Jamal B. Williams & Qing Cao & Wei Wang & Young-Ho Lee & Luye Qin & Ping Zhong & Yong Ren & Kaijie Ma & Zhen Yan, 2023. "Inhibition of histone methyltransferase Smyd3 rescues NMDAR and cognitive deficits in a tauopathy mouse model," Nature Communications, Nature, vol. 14(1), pages 1-13, December.

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