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Human embryonic-stem-cell-derived cardiomyocytes regenerate non-human primate hearts

Author

Listed:
  • James J. H. Chong

    (Center for Cardiovascular Biology, University of Washington
    Institute for Stem Cell and Regenerative Medicine, University of Washington
    Department of Cardiology Westmead Hospital
    School of Medicine, University of Sydney)

  • Xiulan Yang

    (Center for Cardiovascular Biology, University of Washington
    Institute for Stem Cell and Regenerative Medicine, University of Washington
    University of Washington)

  • Creighton W. Don

    (University of Washington)

  • Elina Minami

    (Center for Cardiovascular Biology, University of Washington
    Institute for Stem Cell and Regenerative Medicine, University of Washington
    University of Washington
    University of Washington)

  • Yen-Wen Liu

    (Center for Cardiovascular Biology, University of Washington
    Institute for Stem Cell and Regenerative Medicine, University of Washington
    University of Washington)

  • Jill J. Weyers

    (Center for Cardiovascular Biology, University of Washington
    Institute for Stem Cell and Regenerative Medicine, University of Washington
    University of Washington)

  • William M. Mahoney

    (Center for Cardiovascular Biology, University of Washington
    Institute for Stem Cell and Regenerative Medicine, University of Washington
    University of Washington)

  • Benjamin Van Biber

    (Center for Cardiovascular Biology, University of Washington
    Institute for Stem Cell and Regenerative Medicine, University of Washington
    University of Washington)

  • Savannah M. Cook

    (Institute for Stem Cell and Regenerative Medicine, University of Washington)

  • Nathan J. Palpant

    (Center for Cardiovascular Biology, University of Washington
    Institute for Stem Cell and Regenerative Medicine, University of Washington
    University of Washington)

  • Jay A. Gantz

    (Center for Cardiovascular Biology, University of Washington
    Institute for Stem Cell and Regenerative Medicine, University of Washington
    University of Washington
    University of Washington)

  • James A. Fugate

    (Center for Cardiovascular Biology, University of Washington
    Institute for Stem Cell and Regenerative Medicine, University of Washington
    University of Washington)

  • Veronica Muskheli

    (Center for Cardiovascular Biology, University of Washington
    Institute for Stem Cell and Regenerative Medicine, University of Washington
    University of Washington)

  • G. Michael Gough

    (Washington National Primate Research Center, University of Washington)

  • Keith W. Vogel

    (Washington National Primate Research Center, University of Washington)

  • Cliff A. Astley

    (Washington National Primate Research Center, University of Washington)

  • Charlotte E. Hotchkiss

    (Washington National Primate Research Center, University of Washington)

  • Audrey Baldessari

    (Washington National Primate Research Center, University of Washington)

  • Lil Pabon

    (Center for Cardiovascular Biology, University of Washington
    Institute for Stem Cell and Regenerative Medicine, University of Washington
    University of Washington)

  • Hans Reinecke

    (Center for Cardiovascular Biology, University of Washington
    Institute for Stem Cell and Regenerative Medicine, University of Washington
    University of Washington)

  • Edward A. Gill

    (University of Washington)

  • Veronica Nelson

    (Fred Hutchinson Cancer Research Center)

  • Hans-Peter Kiem

    (University of Washington
    Fred Hutchinson Cancer Research Center)

  • Michael A. Laflamme

    (Center for Cardiovascular Biology, University of Washington
    Institute for Stem Cell and Regenerative Medicine, University of Washington
    University of Washington)

  • Charles E. Murry

    (Center for Cardiovascular Biology, University of Washington
    Institute for Stem Cell and Regenerative Medicine, University of Washington
    University of Washington
    University of Washington)

Abstract

Regeneration of the heart muscle after myocardial infarction with cardiomyocytes derived from human embryonic stem cells is demonstrated in non-human primates, with the grafts showing evidence of electromechanical coupling, although they were also associated with non-fatal arrhythmias.

Suggested Citation

  • James J. H. Chong & Xiulan Yang & Creighton W. Don & Elina Minami & Yen-Wen Liu & Jill J. Weyers & William M. Mahoney & Benjamin Van Biber & Savannah M. Cook & Nathan J. Palpant & Jay A. Gantz & James, 2014. "Human embryonic-stem-cell-derived cardiomyocytes regenerate non-human primate hearts," Nature, Nature, vol. 510(7504), pages 273-277, June.
    • Handle: RePEc:nat:nature:v:510:y:2014:i:7504:d:10.1038_nature13233
    DOI: 10.1038/nature13233
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