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The unfolded protein response governs integrity of the haematopoietic stem-cell pool during stress

Author

Listed:
  • Peter van Galen

    (Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario M5G 2M9, Canada
    University of Toronto, Toronto, Ontario M5S 1A8, Canada)

  • Antonija Kreso

    (Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario M5G 2M9, Canada
    University of Toronto, Toronto, Ontario M5S 1A8, Canada)

  • Nathan Mbong

    (Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario M5G 2M9, Canada
    University of Toronto, Toronto, Ontario M5S 1A8, Canada)

  • David G. Kent

    (Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 0XY, UK)

  • Timothy Fitzmaurice

    (School of Clinical Medicine, Addenbrookes Hospital, University of Cambridge, Cambridge CB2 0QQ, UK)

  • Joseph E. Chambers

    (Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 0XY, UK)

  • Stephanie Xie

    (Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario M5G 2M9, Canada
    University of Toronto, Toronto, Ontario M5S 1A8, Canada)

  • Elisa Laurenti

    (Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario M5G 2M9, Canada
    University of Toronto, Toronto, Ontario M5S 1A8, Canada)

  • Karin Hermans

    (Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario M5G 2M9, Canada
    University of Toronto, Toronto, Ontario M5S 1A8, Canada)

  • Kolja Eppert

    (McGill University and the Research Institute of the McGill University Health Centre, Westmount, Québec H3Z 2Z3, Canada)

  • Stefan J. Marciniak

    (Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 0XY, UK)

  • Jane C. Goodall

    (School of Clinical Medicine, Addenbrookes Hospital, University of Cambridge, Cambridge CB2 0QQ, UK)

  • Anthony R. Green

    (Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 0XY, UK)

  • Bradly G. Wouters

    (Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario M5G 2M9, Canada)

  • Erno Wienholds

    (Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario M5G 2M9, Canada
    University of Toronto, Toronto, Ontario M5S 1A8, Canada)

  • John E. Dick

    (Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario M5G 2M9, Canada
    University of Toronto, Toronto, Ontario M5S 1A8, Canada)

Abstract

Molecular, pharmacological and functional data show that haematopoietic stem cells (HSCs) are predisposed to ER-stress-mediated apoptosis compared to closely related progenitors; a framework for understanding how stress signalling is coordinated within the hematopoietic hierarchy and integrated with stemness is provided, and may have implications for the improvement of clinical transplantation of HSCs.

Suggested Citation

  • Peter van Galen & Antonija Kreso & Nathan Mbong & David G. Kent & Timothy Fitzmaurice & Joseph E. Chambers & Stephanie Xie & Elisa Laurenti & Karin Hermans & Kolja Eppert & Stefan J. Marciniak & Jane , 2014. "The unfolded protein response governs integrity of the haematopoietic stem-cell pool during stress," Nature, Nature, vol. 510(7504), pages 268-272, June.
    • Handle: RePEc:nat:nature:v:510:y:2014:i:7504:d:10.1038_nature13228
    DOI: 10.1038/nature13228
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    Cited by:

    1. Zijian Fang & Giuditta Corbizi Fattori & Thomas McKerrell & Rebecca H. Boucher & Aimee Jackson & Rachel S. Fletcher & Dorian Forte & Jose-Ezequiel Martin & Sonia Fox & James Roberts & Rachel Glover & , 2023. "Tamoxifen for the treatment of myeloproliferative neoplasms: A Phase II clinical trial and exploratory analysis," Nature Communications, Nature, vol. 14(1), pages 1-21, December.
    2. Xiaofan Sun & Yue Li & Juan Du & Fangshu Liu & Caiping Wu & Weihao Xiao & Guopan Yu & Xiaowei Chen & Robert Peter Gale & Hui Zeng, 2025. "Targeting ceramide transfer protein sensitizes AML to FLT3 inhibitors via a GRP78-ATF6-CHOP axis," Nature Communications, Nature, vol. 16(1), pages 1-17, December.
    3. Florisela Herrejon Chavez & Hanzhi Luo & Paolo Cifani & Alli Pine & Eren L. Chu & Suhasini Joshi & Ersilia Barin & Alexandra Schurer & Mandy Chan & Kathryn Chang & Grace Y. Q. Han & Aspen J. Pierson &, 2023. "RNA binding protein SYNCRIP maintains proteostasis and self-renewal of hematopoietic stem and progenitor cells," Nature Communications, Nature, vol. 14(1), pages 1-19, December.
    4. Kim Vanuytsel & Carlos Villacorta-Martin & Jonathan Lindstrom-Vautrin & Zhe Wang & Wilfredo F. Garcia-Beltran & Vladimir Vrbanac & Dylan Parsons & Evan C. Lam & Taylor M. Matte & Todd W. Dowrey & Sara, 2022. "Multi-modal profiling of human fetal liver hematopoietic stem cells reveals the molecular signature of engraftment," Nature Communications, Nature, vol. 13(1), pages 1-13, December.

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