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The different shades of fat

Author

Listed:
  • Vivian Peirce

    (University of Cambridge Metabolic Research Laboratories, Level 4, Wellcome Trust-MRC Institute of Metabolic Science
    Addenbrooke's Hospital)

  • Stefania Carobbio

    (University of Cambridge Metabolic Research Laboratories, Level 4, Wellcome Trust-MRC Institute of Metabolic Science
    Addenbrooke's Hospital
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus)

  • Antonio Vidal-Puig

    (University of Cambridge Metabolic Research Laboratories, Level 4, Wellcome Trust-MRC Institute of Metabolic Science
    Addenbrooke's Hospital
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus)

Abstract

Our understanding of adipose tissue biology has progressed rapidly since the turn of the century. White adipose tissue has emerged as a key determinant of healthy metabolism and metabolic dysfunction. This realization is paralleled only by the confirmation that adult humans have heat-dissipating brown adipose tissue, an important contributor to energy balance and a possible therapeutic target for the treatment of metabolic disease. We propose that the development of successful strategies to target brown and white adipose tissues will depend on investigations that elucidate their developmental origins and cell-type-specific functional regulators.

Suggested Citation

  • Vivian Peirce & Stefania Carobbio & Antonio Vidal-Puig, 2014. "The different shades of fat," Nature, Nature, vol. 510(7503), pages 76-83, June.
    • Handle: RePEc:nat:nature:v:510:y:2014:i:7503:d:10.1038_nature13477
    DOI: 10.1038/nature13477
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    Cited by:

    1. Chang-Hyung Lee & Young-A Choi & Sung-Jin Heo & Parkyong Song, 2021. "The Effect of Hyperbaric Therapy on Brown Adipose Tissue in Rats," IJERPH, MDPI, vol. 18(17), pages 1-8, August.

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