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Sphingolipid metabolites in inflammatory disease

Author

Listed:
  • Michael Maceyka

    (Virginia Commonwealth University School of Medicine)

  • Sarah Spiegel

    (Virginia Commonwealth University School of Medicine)

Abstract

Sphingolipids are ubiquitous building blocks of eukaryotic cell membranes. Progress in our understanding of sphingolipid metabolism, state-of-the-art sphingolipidomic approaches and animal models have generated a large body of evidence demonstrating that sphingolipid metabolites, particularly ceramide and sphingosine-1-phosphate, are signalling molecules that regulate a diverse range of cellular processes that are important in immunity, inflammation and inflammatory disorders. Recent insights into the molecular mechanisms of action of sphingolipid metabolites and new perspectives on their roles in regulating chronic inflammation have been reported. The knowledge gained in this emerging field will aid in the development of new therapeutic options for inflammatory disorders.

Suggested Citation

  • Michael Maceyka & Sarah Spiegel, 2014. "Sphingolipid metabolites in inflammatory disease," Nature, Nature, vol. 510(7503), pages 58-67, June.
    • Handle: RePEc:nat:nature:v:510:y:2014:i:7503:d:10.1038_nature13475
    DOI: 10.1038/nature13475
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    Cited by:

    1. Po-Wei Chen & Luis L Fonseca & Yusuf A Hannun & Eberhard O Voit, 2016. "Analysis of the Involvement of Different Ceramide Variants in the Response to Hydroxyurea Stress in Baker's Yeast," PLOS ONE, Public Library of Science, vol. 11(1), pages 1-20, January.

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