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Focused specificity of intestinal TH17 cells towards commensal bacterial antigens

Author

Listed:
  • Yi Yang

    (The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine)

  • Miriam B. Torchinsky

    (The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine)

  • Michael Gobert

    (The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine)

  • Huizhong Xiong

    (The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine)

  • Mo Xu

    (The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine)

  • Jonathan L. Linehan

    (Center for Immunology, University of Minnesota Medical School
    Present address: Mucosal Immunology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892-0485, USA.)

  • Francis Alonzo

    (New York University School of Medicine)

  • Charles Ng

    (The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine)

  • Alessandra Chen

    (The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine)

  • Xiyao Lin

    (The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine)

  • Andrew Sczesnak

    (The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine)

  • Jia-Jun Liao

    (The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine)

  • Victor J. Torres

    (New York University School of Medicine)

  • Marc K. Jenkins

    (Center for Immunology, University of Minnesota Medical School)

  • Juan J. Lafaille

    (The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine)

  • Dan R. Littman

    (The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine
    Howard Hughes Medical Institute, New York University School of Medicine)

Abstract

Segmented filamentous bacteria drive the acquisition of the TH17 phenotype in an antigen-specific manner; these findings begin to elucidate how gut-induced TH17 cells can contribute to distal organ-specific autoimmune disease.

Suggested Citation

  • Yi Yang & Miriam B. Torchinsky & Michael Gobert & Huizhong Xiong & Mo Xu & Jonathan L. Linehan & Francis Alonzo & Charles Ng & Alessandra Chen & Xiyao Lin & Andrew Sczesnak & Jia-Jun Liao & Victor J. , 2014. "Focused specificity of intestinal TH17 cells towards commensal bacterial antigens," Nature, Nature, vol. 510(7503), pages 152-156, June.
    • Handle: RePEc:nat:nature:v:510:y:2014:i:7503:d:10.1038_nature13279
    DOI: 10.1038/nature13279
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