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Nociceptive sensory neurons drive interleukin-23-mediated psoriasiform skin inflammation

Author

Listed:
  • Lorena Riol-Blanco

    (Harvard Medical School)

  • Jose Ordovas-Montanes

    (Harvard Medical School)

  • Mario Perro

    (Harvard Medical School)

  • Elena Naval

    (Harvard Medical School)

  • Aude Thiriot

    (Harvard Medical School)

  • David Alvarez

    (Harvard Medical School)

  • Silke Paust

    (Harvard Medical School
    Present address: Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77030, USA.)

  • John N. Wood

    (Institute for Biomedical Research, University College London, London WC1E 6BT, UK)

  • Ulrich H. von Andrian

    (Harvard Medical School)

Abstract

In mice, it is possible to induce a psoriasis-like condition by applying imiquimod; here, the production of interleukin-23 that is stimulated by such skin inflammation is shown to depend on the interaction of nociceptors expressing the Nav1.8 and TRPV1 channels with skin-resident dendritic cells.

Suggested Citation

  • Lorena Riol-Blanco & Jose Ordovas-Montanes & Mario Perro & Elena Naval & Aude Thiriot & David Alvarez & Silke Paust & John N. Wood & Ulrich H. von Andrian, 2014. "Nociceptive sensory neurons drive interleukin-23-mediated psoriasiform skin inflammation," Nature, Nature, vol. 510(7503), pages 157-161, June.
    • Handle: RePEc:nat:nature:v:510:y:2014:i:7503:d:10.1038_nature13199
    DOI: 10.1038/nature13199
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    Cited by:

    1. Shang-Ze Li & Qi-Peng Shu & Hai-Meng Zhou & Yu-Ying Liu & Meng-Qi Fan & Xin-Yi Liang & Lin-Zhi Qi & Ya-Nan He & Xue-Yi Liu & Xue-Hua Du & Xi-Chen Huang & Yu-Zhen Chen & Run-Lei Du & Yue-Xiu Liang & Xi, 2024. "CLK2 mediates IκBα-independent early termination of NF-κB activation by inducing cytoplasmic redistribution and degradation," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    2. Min Jung & Michelle Dourado & James Maksymetz & Amanda Jacobson & Benjamin I. Laufer & Miriam Baca & Oded Foreman & David H. Hackos & Lorena Riol-Blanco & Joshua S. Kaminker, 2023. "Cross-species transcriptomic atlas of dorsal root ganglia reveals species-specific programs for sensory function," Nature Communications, Nature, vol. 14(1), pages 1-15, December.

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