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Clonal selection in the germinal centre by regulated proliferation and hypermutation

Author

Listed:
  • Alexander D. Gitlin

    (Laboratory of Molecular Immunology, The Rockefeller University)

  • Ziv Shulman

    (Laboratory of Molecular Immunology, The Rockefeller University)

  • Michel C. Nussenzweig

    (Laboratory of Molecular Immunology, The Rockefeller University
    Howard Hughes Medical Institute, The Rockefeller University)

Abstract

Clonal expansion and hypermutation of B cells in the germinal centre are regulated by the amount of antigen that the B cells present to follicular helper T cells.

Suggested Citation

  • Alexander D. Gitlin & Ziv Shulman & Michel C. Nussenzweig, 2014. "Clonal selection in the germinal centre by regulated proliferation and hypermutation," Nature, Nature, vol. 509(7502), pages 637-640, May.
    • Handle: RePEc:nat:nature:v:509:y:2014:i:7502:d:10.1038_nature13300
    DOI: 10.1038/nature13300
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    Cited by:

    1. Dimitra Zotos & Isaak Quast & Connie S. N. Li-Wai-Suen & Craig I. McKenzie & Marcus J. Robinson & Andrey Kan & Gordon K. Smyth & Philip D. Hodgkin & David M. Tarlinton, 2021. "The concerted change in the distribution of cell cycle phases and zone composition in germinal centers is regulated by IL-21," Nature Communications, Nature, vol. 12(1), pages 1-14, December.
    2. Thomas Hu & Mayar Allam & Shuangyi Cai & Walter Henderson & Brian Yueh & Aybuke Garipcan & Anton V. Ievlev & Maryam Afkarian & Semir Beyaz & Ahmet F. Coskun, 2023. "Single-cell spatial metabolomics with cell-type specific protein profiling for tissue systems biology," Nature Communications, Nature, vol. 14(1), pages 1-20, December.
    3. Liat Stoler-Barak & Ethan Harris & Ayelet Peres & Hadas Hezroni & Mirela Kuka & Pietro Lucia & Amalie Grenov & Neta Gurwicz & Meital Kupervaser & Bon Ham Yip & Matteo Iannacone & Gur Yaari & John D. C, 2023. "B cell class switch recombination is regulated by DYRK1A through MSH6 phosphorylation," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    4. Julia Merkenschlager & Riza-Maria Berz & Victor Ramos & Maximilian Uhlig & Andrew J. MacLean & Carla R. Nowosad & Thiago Y. Oliveira & Michel C. Nussenzweig, 2023. "Continually recruited naïve T cells contribute to the follicular helper and regulatory T cell pools in germinal centers," Nature Communications, Nature, vol. 14(1), pages 1-11, December.

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