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Piezo2 is required for Merkel-cell mechanotransduction

Author

Listed:
  • Seung-Hyun Woo

    (Howard Hughes Medical Institute, Molecular and Cellular Neuroscience, The Scripps Research Institute)

  • Sanjeev Ranade

    (Howard Hughes Medical Institute, Molecular and Cellular Neuroscience, The Scripps Research Institute)

  • Andy D. Weyer

    (Neurobiology, and Anatomy, Medical College of Wisconsin)

  • Adrienne E. Dubin

    (Howard Hughes Medical Institute, Molecular and Cellular Neuroscience, The Scripps Research Institute)

  • Yoshichika Baba

    (Columbia University)

  • Zhaozhu Qiu

    (Howard Hughes Medical Institute, Molecular and Cellular Neuroscience, The Scripps Research Institute
    Genomics Institute of the Novartis Research Foundation)

  • Matt Petrus

    (Genomics Institute of the Novartis Research Foundation)

  • Takashi Miyamoto

    (Howard Hughes Medical Institute, Molecular and Cellular Neuroscience, The Scripps Research Institute
    Present address: Gladstone Institute of Neurological Disease, San Francisco, California 94158, USA.)

  • Kritika Reddy

    (Genomics Institute of the Novartis Research Foundation)

  • Ellen A. Lumpkin

    (Columbia University)

  • Cheryl L. Stucky

    (Neurobiology, and Anatomy, Medical College of Wisconsin)

  • Ardem Patapoutian

    (Howard Hughes Medical Institute, Molecular and Cellular Neuroscience, The Scripps Research Institute)

Abstract

A mouse study shows that non-neuronal epidermal Merkel cells aid fine-touch perception in the skin through their expression of the Piezo2 mechanosensitive cation channel which then actively tunes the response to touch in adjacent somatosensory neurons.

Suggested Citation

  • Seung-Hyun Woo & Sanjeev Ranade & Andy D. Weyer & Adrienne E. Dubin & Yoshichika Baba & Zhaozhu Qiu & Matt Petrus & Takashi Miyamoto & Kritika Reddy & Ellen A. Lumpkin & Cheryl L. Stucky & Ardem Patap, 2014. "Piezo2 is required for Merkel-cell mechanotransduction," Nature, Nature, vol. 509(7502), pages 622-626, May.
    • Handle: RePEc:nat:nature:v:509:y:2014:i:7502:d:10.1038_nature13251
    DOI: 10.1038/nature13251
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    Citations

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    Cited by:

    1. Jonathan Madar & Namrata Tiwari & Cristina Smith & Divya Sharma & Shanwei Shen & Alsiddig Elmahdi & Liya Y. Qiao, 2023. "Piezo2 regulates colonic mechanical sensitivity in a sex specific manner in mice," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    2. Martina Nicoletti & Letizia Chiodo & Alessandro Loppini, 2021. "Biophysics and Modeling of Mechanotransduction in Neurons: A Review," Mathematics, MDPI, vol. 9(4), pages 1-32, February.
    3. Sijia Xu & Jie-Xiang Yu & Hongshuang Guo & Shu Tian & You Long & Jing Yang & Lei Zhang, 2023. "Force-induced ion generation in zwitterionic hydrogels for a sensitive silent-speech sensor," Nature Communications, Nature, vol. 14(1), pages 1-11, December.
    4. Luis O. Romero & Rebeca Caires & A. Kaitlyn Victor & Juanma Ramirez & Francisco J. Sierra-Valdez & Patrick Walsh & Vincent Truong & Jungsoo Lee & Ugo Mayor & Lawrence T. Reiter & Valeria Vásquez & Jul, 2023. "Linoleic acid improves PIEZO2 dysfunction in a mouse model of Angelman Syndrome," Nature Communications, Nature, vol. 14(1), pages 1-20, December.
    5. Julia Ojeda-Alonso & Laura Calvo-Enrique & Ricardo Paricio-Montesinos & Rakesh Kumar & Ming-Dong Zhang & James F. A. Poulet & Patrik Ernfors & Gary R. Lewin, 2024. "Sensory Schwann cells set perceptual thresholds for touch and selectively regulate mechanical nociception," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    6. Gregory J Gerling & Lingtian Wan & Benjamin U Hoffman & Yuxiang Wang & Ellen A Lumpkin, 2018. "Computation predicts rapidly adapting mechanotransduction currents cannot account for tactile encoding in Merkel cell-neurite complexes," PLOS Computational Biology, Public Library of Science, vol. 14(6), pages 1-21, June.
    7. Huimin Li & Jianle Lin & Shuxin Lin & Haojie Zhong & Bowei Jiang & Xinghui Liu & Weisheng Wu & Weiwei Li & Emad Iranmanesh & Zhongyi Zhou & Wenjun Li & Kai Wang, 2024. "A bioinspired tactile scanner for computer haptics," Nature Communications, Nature, vol. 15(1), pages 1-12, December.
    8. Jeong Han Lee & Maria C. Perez-Flores & Seojin Park & Hyo Jeong Kim & Yingying Chen & Mincheol Kang & Jennifer Kersigo & Jinsil Choi & Phung N. Thai & Ryan L. Woltz & Dolores Columba Perez-Flores & Gu, 2024. "The Piezo channel is a mechano-sensitive complex component in the mammalian inner ear hair cell," Nature Communications, Nature, vol. 15(1), pages 1-17, December.

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