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Copper is required for oncogenic BRAF signalling and tumorigenesis

Author

Listed:
  • Donita C. Brady

    (Duke University Medical Center)

  • Matthew S. Crowe

    (Duke University Medical Center)

  • Michelle L. Turski

    (Duke University Medical Center)

  • G. Aaron Hobbs

    (University of North Carolina at Chapel Hill)

  • Xiaojie Yao

    (Duke University Medical Center)

  • Apirat Chaikuad

    (Target Discovery Institute and Structural Genomics Consortium, University of Oxford, Oxford OX3 7DQ, UK)

  • Stefan Knapp

    (Target Discovery Institute and Structural Genomics Consortium, University of Oxford, Oxford OX3 7DQ, UK)

  • Kunhong Xiao

    (Duke University Medical Center)

  • Sharon L. Campbell

    (University of North Carolina at Chapel Hill)

  • Dennis J. Thiele

    (Duke University Medical Center)

  • Christopher M. Counter

    (Duke University Medical Center
    Duke University Medical Center)

Abstract

Tumorigenesis driven by the oncogene BRAFV600E is shown both to depend on the BRAF substrates MEK1/2 associating with copper, and to be sensitive to copper-chelating drugs, suggesting merit in testing such drugs for the treatment of BRAF mutation-positive cancers.

Suggested Citation

  • Donita C. Brady & Matthew S. Crowe & Michelle L. Turski & G. Aaron Hobbs & Xiaojie Yao & Apirat Chaikuad & Stefan Knapp & Kunhong Xiao & Sharon L. Campbell & Dennis J. Thiele & Christopher M. Counter, 2014. "Copper is required for oncogenic BRAF signalling and tumorigenesis," Nature, Nature, vol. 509(7501), pages 492-496, May.
    • Handle: RePEc:nat:nature:v:509:y:2014:i:7501:d:10.1038_nature13180
    DOI: 10.1038/nature13180
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