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Structural basis of Sec-independent membrane protein insertion by YidC

Author

Listed:
  • Kaoru Kumazaki

    (Graduate School of Science, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan
    Global Research Cluster, RIKEN, 2-1 Hirosawa, Wako-shi, Saitama 351-0198, Japan)

  • Shinobu Chiba

    (Faculty of Life Sciences, Kyoto Sangyo University, Motoyama, Kamigamo, Kita-ku, Kyoto 603-8555, Japan)

  • Mizuki Takemoto

    (Graduate School of Science, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan
    Global Research Cluster, RIKEN, 2-1 Hirosawa, Wako-shi, Saitama 351-0198, Japan)

  • Arata Furukawa

    (Graduate School of Biological Sciences, Nara Institute of Science and Technology, 8916-5 Takayama-cho, Ikoma, Nara 630-0192, Japan)

  • Ken-ichi Nishiyama

    (Cryobiofrontier Research Center, Faculty of Agriculture, Iwate University, 3-18-8 Ueda, Morioka, Iwate 020-8550, Japan)

  • Yasunori Sugano

    (Graduate School of Biological Sciences, Nara Institute of Science and Technology, 8916-5 Takayama-cho, Ikoma, Nara 630-0192, Japan)

  • Takaharu Mori

    (Theoretical Molecular Science Laboratory, RIKEN, 2-1 Hirosawa, Wako-shi, Saitama 351-0198, Japan)

  • Naoshi Dohmae

    (Global Research Cluster, RIKEN, 2-1 Hirosawa, Wako-shi, Saitama 351-0198, Japan)

  • Kunio Hirata

    (SR Life Science Instrumentation Unit, RIKEN SPring-8 Center, 1-1-1 Kouto, Sayo-cho, Sayo-gun, Hyogo 679-5148, Japan)

  • Yoshiko Nakada-Nakura

    (Graduate School of Medicine, Kyoto University, Yoshidakonoe-cho, Sakyo-ku, Kyoto 606-8501, Japan)

  • Andrés D. Maturana

    (Graduate School of Bioagricultural Sciences, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8601, Japan)

  • Yoshiki Tanaka

    (Graduate School of Biological Sciences, Nara Institute of Science and Technology, 8916-5 Takayama-cho, Ikoma, Nara 630-0192, Japan)

  • Hiroyuki Mori

    (Institute for Virus Research, Kyoto University, Shogoin Kawara-cho, Sakyo-ku, Kyoto 606-8507, Japan)

  • Yuji Sugita

    (Theoretical Molecular Science Laboratory, RIKEN, 2-1 Hirosawa, Wako-shi, Saitama 351-0198, Japan)

  • Fumio Arisaka

    (Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, Nagatsuta-cho, Midori-ku, Yokohama, Kanagawa 226-8503, Japan)

  • Koreaki Ito

    (Faculty of Life Sciences, Kyoto Sangyo University, Motoyama, Kamigamo, Kita-ku, Kyoto 603-8555, Japan)

  • Ryuichiro Ishitani

    (Graduate School of Science, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan
    Global Research Cluster, RIKEN, 2-1 Hirosawa, Wako-shi, Saitama 351-0198, Japan)

  • Tomoya Tsukazaki

    (Graduate School of Biological Sciences, Nara Institute of Science and Technology, 8916-5 Takayama-cho, Ikoma, Nara 630-0192, Japan
    JST, PRESTO, 4-1-8 Honcho, Kawaguchi, Saitama 332-0012, Japan)

  • Osamu Nureki

    (Graduate School of Science, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan
    Global Research Cluster, RIKEN, 2-1 Hirosawa, Wako-shi, Saitama 351-0198, Japan)

Abstract

The crystal structure of the bacterial protein YidC is reported, together with a structure-based functional analysis, providing insight into the role of YidC in inserting single-spanning membrane proteins into the membrane.

Suggested Citation

  • Kaoru Kumazaki & Shinobu Chiba & Mizuki Takemoto & Arata Furukawa & Ken-ichi Nishiyama & Yasunori Sugano & Takaharu Mori & Naoshi Dohmae & Kunio Hirata & Yoshiko Nakada-Nakura & Andrés D. Maturana & Y, 2014. "Structural basis of Sec-independent membrane protein insertion by YidC," Nature, Nature, vol. 509(7501), pages 516-520, May.
    • Handle: RePEc:nat:nature:v:509:y:2014:i:7501:d:10.1038_nature13167
    DOI: 10.1038/nature13167
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    Citations

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    Cited by:

    1. Keigo Fujiwara & Naoko Tsuji & Mayu Yoshida & Hiraku Takada & Shinobu Chiba, 2024. "Patchy and widespread distribution of bacterial translation arrest peptides associated with the protein localization machinery," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    2. Pawel R. Laskowski & Kristyna Pluhackova & Maximilian Haase & Brian M. Lang & Gisela Nagler & Andreas Kuhn & Daniel J. Müller, 2021. "Monitoring the binding and insertion of a single transmembrane protein by an insertase," Nature Communications, Nature, vol. 12(1), pages 1-11, December.

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