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Protective mucosal immunity mediated by epithelial CD1d and IL-10

Author

Listed:
  • Torsten Olszak

    (Hepatology, and Endoscopy, Brigham and Women’s Hospital, Harvard Medical School)

  • Joana F. Neves

    (Hepatology, and Endoscopy, Brigham and Women’s Hospital, Harvard Medical School)

  • C. Marie Dowds

    (University Medical Center Schleswig-Holstein, 24105 Kiel, Germany)

  • Kristi Baker

    (Hepatology, and Endoscopy, Brigham and Women’s Hospital, Harvard Medical School)

  • Jonathan Glickman

    (GI Pathology, Miraca Life Sciences)

  • Nicholas O. Davidson

    (Washington University School of Medicine)

  • Chyuan-Sheng Lin

    (Herbert Irving Comprehensive Cancer Center, Columbia University)

  • Christian Jobin

    (University of Florida)

  • Stephan Brand

    (Ludwig Maximilians University, Munich 81377, Germany)

  • Karl Sotlar

    (Institute of Pathology, Ludwig Maximilians University, Munich 80337, Germany)

  • Koichiro Wada

    (Graduate School of Dentistry, Osaka University, Osaka 565-0871, Japan)

  • Kazufumi Katayama

    (Graduate School of Dentistry, Osaka University, Osaka 565-0871, Japan)

  • Atsushi Nakajima

    (Yokohama City University School of Medicine, Yokohama, Kanagawa 236-0027, Japan)

  • Hiroyuki Mizuguchi

    (Laboratory of Biochemistry and Molecular Biology, Graduate School of Pharmaceutical Sciences, Osaka University, Osaka 565-0871, Japan)

  • Kunito Kawasaki

    (Faculty of Life Sciences, Kyoto Sangyo University, Motoyama, Kamigamo, Kita-ku, Kyoto 603-8555, Japan)

  • Kazuhiro Nagata

    (Faculty of Life Sciences, Kyoto Sangyo University, Motoyama, Kamigamo, Kita-ku, Kyoto 603-8555, Japan)

  • Werner Müller

    (Faculty of Life Sciences, University of Manchester, Manchester M13 9PL, UK)

  • Scott B. Snapper

    (Hepatology, and Endoscopy, Brigham and Women’s Hospital, Harvard Medical School
    Hepatology, and Nutrition, Children's Hospital Boston)

  • Stefan Schreiber

    (University Medical Center Schleswig-Holstein, 24105 Kiel, Germany)

  • Arthur Kaser

    (Addenbrooke Hospital, University of Cambridge, Cambridge CB2 0QQ, UK)

  • Sebastian Zeissig

    (Hepatology, and Endoscopy, Brigham and Women’s Hospital, Harvard Medical School
    University Medical Center Schleswig-Holstein, 24105 Kiel, Germany)

  • Richard S. Blumberg

    (Hepatology, and Endoscopy, Brigham and Women’s Hospital, Harvard Medical School)

Abstract

Here, the presentation of lipid antigens by CD1d is shown to induce retrograde anti-inflammatory signalling in intestinal epithelial cells, resulting in the production of IL-10.

Suggested Citation

  • Torsten Olszak & Joana F. Neves & C. Marie Dowds & Kristi Baker & Jonathan Glickman & Nicholas O. Davidson & Chyuan-Sheng Lin & Christian Jobin & Stephan Brand & Karl Sotlar & Koichiro Wada & Kazufumi, 2014. "Protective mucosal immunity mediated by epithelial CD1d and IL-10," Nature, Nature, vol. 509(7501), pages 497-502, May.
    • Handle: RePEc:nat:nature:v:509:y:2014:i:7501:d:10.1038_nature13150
    DOI: 10.1038/nature13150
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    Cited by:

    1. Phillip M. Brailey & Lauren Evans & Juan Carlos López-Rodríguez & Anthony Sinadinos & Victoria Tyrrel & Gavin Kelly & Valerie O’Donnell & Peter Ghazal & Susan John & Patricia Barral, 2022. "CD1d-dependent rewiring of lipid metabolism in macrophages regulates innate immune responses," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    2. Ondrej Suchanek & John R. Ferdinand & Zewen K. Tuong & Sathi Wijeyesinghe & Anita Chandra & Ann-Katrin Clauder & Larissa N. Almeida & Simon Clare & Katherine Harcourt & Christopher J. Ward & Rachael B, 2023. "Tissue-resident B cells orchestrate macrophage polarisation and function," Nature Communications, Nature, vol. 14(1), pages 1-20, December.

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