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Space–time wiring specificity supports direction selectivity in the retina

Author

Listed:
  • Jinseop S. Kim

    (Massachusetts Institute of Technology)

  • Matthew J. Greene

    (Massachusetts Institute of Technology)

  • Aleksandar Zlateski

    (Massachusetts Institute of Technology)

  • Kisuk Lee

    (Massachusetts Institute of Technology)

  • Mark Richardson

    (Massachusetts Institute of Technology
    Present addresses: 601 N 42nd Street, Seattle, Washington 98103, USA (M.R.); Princeton Neuroscience Institute and Computer Science Deptartment, Princeton, New Jersey 08544, USA (H.S.S.); Gatsby Computational Neuroscience Unit, London WC1N 3AR, UK (S.C.T.).)

  • Srinivas C. Turaga

    (Massachusetts Institute of Technology
    Present addresses: 601 N 42nd Street, Seattle, Washington 98103, USA (M.R.); Princeton Neuroscience Institute and Computer Science Deptartment, Princeton, New Jersey 08544, USA (H.S.S.); Gatsby Computational Neuroscience Unit, London WC1N 3AR, UK (S.C.T.).)

  • Michael Purcaro

    (Massachusetts Institute of Technology)

  • Matthew Balkam

    (Massachusetts Institute of Technology)

  • Amy Robinson

    (Massachusetts Institute of Technology)

  • Bardia F. Behabadi

    (Qualcomm Research, 5775 Morehouse Drive)

  • Michael Campos

    (Qualcomm Research, 5775 Morehouse Drive)

  • Winfried Denk

    (Max-Planck Institute for Medical Research, D-69120 Heidelberg, Germany)

  • H. Sebastian Seung

    (Massachusetts Institute of Technology
    Present addresses: 601 N 42nd Street, Seattle, Washington 98103, USA (M.R.); Princeton Neuroscience Institute and Computer Science Deptartment, Princeton, New Jersey 08544, USA (H.S.S.); Gatsby Computational Neuroscience Unit, London WC1N 3AR, UK (S.C.T.).)

Abstract

How does the mammalian retina detect motion? This classic problem in visual neuroscience has remained unsolved for 50 years. In search of clues, here we reconstruct Off-type starburst amacrine cells (SACs) and bipolar cells (BCs) in serial electron microscopic images with help from EyeWire, an online community of ‘citizen neuroscientists’. On the basis of quantitative analyses of contact area and branch depth in the retina, we find evidence that one BC type prefers to wire with a SAC dendrite near the SAC soma, whereas another BC type prefers to wire far from the soma. The near type is known to lag the far type in time of visual response. A mathematical model shows how such ‘space–time wiring specificity’ could endow SAC dendrites with receptive fields that are oriented in space–time and therefore respond selectively to stimuli that move in the outward direction from the soma.

Suggested Citation

  • Jinseop S. Kim & Matthew J. Greene & Aleksandar Zlateski & Kisuk Lee & Mark Richardson & Srinivas C. Turaga & Michael Purcaro & Matthew Balkam & Amy Robinson & Bardia F. Behabadi & Michael Campos & Wi, 2014. "Space–time wiring specificity supports direction selectivity in the retina," Nature, Nature, vol. 509(7500), pages 331-336, May.
    • Handle: RePEc:nat:nature:v:509:y:2014:i:7500:d:10.1038_nature13240
    DOI: 10.1038/nature13240
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