IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v509y2014i7500d10.1038_nature13160.html
   My bibliography  Save this article

T-cell activation by transitory neo-antigens derived from distinct microbial pathways

Author

Listed:
  • Alexandra J. Corbett

    (Peter Doherty Institute for Infection and Immunity, University of Melbourne)

  • Sidonia B. G. Eckle

    (Peter Doherty Institute for Infection and Immunity, University of Melbourne)

  • Richard W. Birkinshaw

    (School of Biomedical Sciences, Monash University)

  • Ligong Liu

    (Institute for Molecular Bioscience, The University of Queensland)

  • Onisha Patel

    (School of Biomedical Sciences, Monash University)

  • Jennifer Mahony

    (School of Microbiology, University College Cork)

  • Zhenjun Chen

    (Peter Doherty Institute for Infection and Immunity, University of Melbourne)

  • Rangsima Reantragoon

    (Peter Doherty Institute for Infection and Immunity, University of Melbourne)

  • Bronwyn Meehan

    (Peter Doherty Institute for Infection and Immunity, University of Melbourne)

  • Hanwei Cao

    (Peter Doherty Institute for Infection and Immunity, University of Melbourne)

  • Nicholas A. Williamson

    (The Bio21 Molecular Science and Biotechnology Institute, University of Melbourne)

  • Richard A. Strugnell

    (Peter Doherty Institute for Infection and Immunity, University of Melbourne)

  • Douwe Van Sinderen

    (School of Microbiology, University College Cork
    Alimentary Pharmabiotic Centre, University College Cork)

  • Jeffrey Y. W. Mak

    (Institute for Molecular Bioscience, The University of Queensland)

  • David P. Fairlie

    (Institute for Molecular Bioscience, The University of Queensland
    Australian Research Council Centre of Excellence in Advanced Molecular Imaging, The University of Queensland)

  • Lars Kjer-Nielsen

    (Peter Doherty Institute for Infection and Immunity, University of Melbourne)

  • Jamie Rossjohn

    (School of Biomedical Sciences, Monash University
    Australian Research Council Centre of Excellence in Advanced Molecular Imaging, Monash University
    Institute of Infection and Immunity, Cardiff University, School of Medicine, Heath Park, Cardiff CF14 4XN, UK)

  • James McCluskey

    (Peter Doherty Institute for Infection and Immunity, University of Melbourne)

Abstract

Activation of mucosal-associated invariant T (MAIT) cells is shown to require key genes encoding an early intermediate in bacterial riboflavin synthesis, 5-amino-6-d-ribitylaminouracil; this reacts non-enzymatically with metabolites to form short-lived antigens that are captured and stabilized by MR1 for presentation to MAIT cells.

Suggested Citation

  • Alexandra J. Corbett & Sidonia B. G. Eckle & Richard W. Birkinshaw & Ligong Liu & Onisha Patel & Jennifer Mahony & Zhenjun Chen & Rangsima Reantragoon & Bronwyn Meehan & Hanwei Cao & Nicholas A. Willi, 2014. "T-cell activation by transitory neo-antigens derived from distinct microbial pathways," Nature, Nature, vol. 509(7500), pages 361-365, May.
  • Handle: RePEc:nat:nature:v:509:y:2014:i:7500:d:10.1038_nature13160
    DOI: 10.1038/nature13160
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature13160
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.

    File URL: https://libkey.io/10.1038/nature13160?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Ann-Christin Gnirck & Marie-Sophie Philipp & Alex Waterhölter & Malte Wunderlich & Nikhat Shaikh & Virginia Adamiak & Lena Henneken & Tobias Kautz & Tingting Xiong & Daniela Klaus & Pascal Tomczyk & M, 2023. "Mucosal-associated invariant T cells contribute to suppression of inflammatory myeloid cells in immune-mediated kidney disease," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    2. Kensuke Shibata & Chihiro Motozono & Masamichi Nagae & Takashi Shimizu & Eri Ishikawa & Daisuke Motooka & Daisuke Okuzaki & Yoshihiro Izumi & Masatomo Takahashi & Nao Fujimori & James B. Wing & Takahi, 2022. "Symbiotic bacteria-dependent expansion of MR1-reactive T cells causes autoimmunity in the absence of Bcl11b," Nature Communications, Nature, vol. 13(1), pages 1-15, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:509:y:2014:i:7500:d:10.1038_nature13160. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.