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Caspase-11 activation requires lysis of pathogen-containing vacuoles by IFN-induced GTPases

Author

Listed:
  • Etienne Meunier

    (Focal Area Infection Biology, Biozentrum, University of Basel, CH-4056 Basel, Switzerland)

  • Mathias S. Dick

    (Focal Area Infection Biology, Biozentrum, University of Basel, CH-4056 Basel, Switzerland)

  • Roland F. Dreier

    (Focal Area Infection Biology, Biozentrum, University of Basel, CH-4056 Basel, Switzerland)

  • Nura Schürmann

    (Focal Area Infection Biology, Biozentrum, University of Basel, CH-4056 Basel, Switzerland)

  • Daniela Kenzelmann Broz

    (University of Basel, CH-4056 Basel, Switzerland)

  • Søren Warming

    (Genentech Inc.)

  • Merone Roose-Girma

    (Genentech Inc.)

  • Dirk Bumann

    (Focal Area Infection Biology, Biozentrum, University of Basel, CH-4056 Basel, Switzerland)

  • Nobuhiko Kayagaki

    (Genentech Inc.)

  • Kiyoshi Takeda

    (Osaka University, Yamadaoka, Suita, Osaka 565-0871, Japan)

  • Masahiro Yamamoto

    (Osaka University, Yamadaoka, Suita, Osaka 565-0871, Japan)

  • Petr Broz

    (Focal Area Infection Biology, Biozentrum, University of Basel, CH-4056 Basel, Switzerland)

Abstract

Interferon-inducible GTPases are required for the release of vacuolar Gram-negative bacteria into the cytoplasm and subsequent inflammasome-mediated caspase-11 activation.

Suggested Citation

  • Etienne Meunier & Mathias S. Dick & Roland F. Dreier & Nura Schürmann & Daniela Kenzelmann Broz & Søren Warming & Merone Roose-Girma & Dirk Bumann & Nobuhiko Kayagaki & Kiyoshi Takeda & Masahiro Yamam, 2014. "Caspase-11 activation requires lysis of pathogen-containing vacuoles by IFN-induced GTPases," Nature, Nature, vol. 509(7500), pages 366-370, May.
    • Handle: RePEc:nat:nature:v:509:y:2014:i:7500:d:10.1038_nature13157
    DOI: 10.1038/nature13157
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    Cited by:

    1. Shouya Feng & Daniel Enosi Tuipulotu & Abhimanu Pandey & Weidong Jing & Cheng Shen & Chinh Ngo & Melkamu B. Tessema & Fei-Ju Li & Daniel Fox & Anukriti Mathur & Anyang Zhao & Runli Wang & Klaus Pfeffe, 2022. "Pathogen-selective killing by guanylate-binding proteins as a molecular mechanism leading to inflammasome signaling," Nature Communications, Nature, vol. 13(1), pages 1-15, December.

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