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Structure of the core ectodomain of the hepatitis C virus envelope glycoprotein 2

Author

Listed:
  • Abdul Ghafoor Khan

    (Center for Advanced Biotechnology and Medicine, Rutgers University, 679 Hoes Lane West, Piscataway, New Jersey 08854, USA)

  • Jillian Whidby

    (Center for Advanced Biotechnology and Medicine, Rutgers University, 679 Hoes Lane West, Piscataway, New Jersey 08854, USA)

  • Matthew T. Miller

    (Center for Advanced Biotechnology and Medicine, Rutgers University, 679 Hoes Lane West, Piscataway, New Jersey 08854, USA)

  • Hannah Scarborough

    (Emory Vaccine Center, Emory University School of Medicine, 100 Woodruff Circle, Atlanta, Georgia 30322, USA)

  • Alexandra V. Zatorski

    (Center for Advanced Biotechnology and Medicine, Rutgers University, 679 Hoes Lane West, Piscataway, New Jersey 08854, USA)

  • Alicja Cygan

    (Center for Advanced Biotechnology and Medicine, Rutgers University, 679 Hoes Lane West, Piscataway, New Jersey 08854, USA)

  • Aryn A. Price

    (Emory Vaccine Center, Emory University School of Medicine, 100 Woodruff Circle, Atlanta, Georgia 30322, USA)

  • Samantha A. Yost

    (Center for Advanced Biotechnology and Medicine, Rutgers University, 679 Hoes Lane West, Piscataway, New Jersey 08854, USA)

  • Caitlin D. Bohannon

    (Emory Vaccine Center, Emory University School of Medicine, 100 Woodruff Circle, Atlanta, Georgia 30322, USA)

  • Joshy Jacob

    (Emory Vaccine Center, Emory University School of Medicine, 100 Woodruff Circle, Atlanta, Georgia 30322, USA)

  • Arash Grakoui

    (Emory Vaccine Center, Emory University School of Medicine, 100 Woodruff Circle, Atlanta, Georgia 30322, USA
    Emory University School of Medicine, 100 Woodruff Circle, Atlanta, Georgia 30322, USA)

  • Joseph Marcotrigiano

    (Center for Advanced Biotechnology and Medicine, Rutgers University, 679 Hoes Lane West, Piscataway, New Jersey 08854, USA)

Abstract

The crystal structure of the core domain of the hepatitis C virus surface glycoprotein E2 has been solved; the structure shows that, contrary to expectation, E2 is unlikely to be the viral fusion protein.

Suggested Citation

  • Abdul Ghafoor Khan & Jillian Whidby & Matthew T. Miller & Hannah Scarborough & Alexandra V. Zatorski & Alicja Cygan & Aryn A. Price & Samantha A. Yost & Caitlin D. Bohannon & Joshy Jacob & Arash Grako, 2014. "Structure of the core ectodomain of the hepatitis C virus envelope glycoprotein 2," Nature, Nature, vol. 509(7500), pages 381-384, May.
    • Handle: RePEc:nat:nature:v:509:y:2014:i:7500:d:10.1038_nature13117
    DOI: 10.1038/nature13117
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    Cited by:

    1. Matthew C. Metcalf & Benjamin M. Janus & Rui Yin & Ruixue Wang & Johnathan D. Guest & Edwin Pozharski & Mansun Law & Roy A. Mariuzza & Eric A. Toth & Brian G. Pierce & Thomas R. Fuerst & Gilad Ofek, 2023. "Structure of engineered hepatitis C virus E1E2 ectodomain in complex with neutralizing antibodies," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    2. Ashish Kumar & Tiana C. Rohe & Elizabeth J. Elrod & Abdul G. Khan & Altaira D. Dearborn & Ryan Kissinger & Arash Grakoui & Joseph Marcotrigiano, 2023. "Regions of hepatitis C virus E2 required for membrane association," Nature Communications, Nature, vol. 14(1), pages 1-10, December.
    3. Kwinten Sliepen & Laura Radić & Joan Capella-Pujol & Yasunori Watanabe & Ian Zon & Ana Chumbe & Wen-Hsin Lee & Marlon Gast & Jelle Koopsen & Sylvie Koekkoek & Iván Moral-Sánchez & Philip J. M. Brouwer, 2022. "Induction of cross-neutralizing antibodies by a permuted hepatitis C virus glycoprotein nanoparticle vaccine candidate," Nature Communications, Nature, vol. 13(1), pages 1-16, December.

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