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NRROS negatively regulates reactive oxygen species during host defence and autoimmunity

Author

Listed:
  • Rajkumar Noubade

    (Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA
    Present addresses: Flexus Biosciences, 75 Shoreway Road, Suite D, San Carlos, California 94070, USA (R.N.); American Society for Biochemistry and Molecular Biology, 11200 Rockville Pike, Suite 302, Rockville, Maryland 20852, USA (P.A.V.).)

  • Kit Wong

    (Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA)

  • Naruhisa Ota

    (Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA)

  • Sascha Rutz

    (Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA)

  • Celine Eidenschenk

    (Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA)

  • Patricia A. Valdez

    (Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA
    Present addresses: Flexus Biosciences, 75 Shoreway Road, Suite D, San Carlos, California 94070, USA (R.N.); American Society for Biochemistry and Molecular Biology, 11200 Rockville Pike, Suite 302, Rockville, Maryland 20852, USA (P.A.V.).)

  • Jiabing Ding

    (Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA)

  • Ivan Peng

    (Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA)

  • Andrew Sebrell

    (Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA)

  • Patrick Caplazi

    (Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA)

  • Jason DeVoss

    (Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA)

  • Robert H. Soriano

    (Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA)

  • Tao Sai

    (Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA)

  • Rongze Lu

    (Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA)

  • Zora Modrusan

    (Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA)

  • Jason Hackney

    (Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA)

  • Wenjun Ouyang

    (Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA)

Abstract

The leucine-rich repeat protein NRROS which resides in the endoplasmic reticulum regulates phagocytic NADPH oxidase, minimizing collateral tissue damage caused by reactive oxygen species during inflammatory processes.

Suggested Citation

  • Rajkumar Noubade & Kit Wong & Naruhisa Ota & Sascha Rutz & Celine Eidenschenk & Patricia A. Valdez & Jiabing Ding & Ivan Peng & Andrew Sebrell & Patrick Caplazi & Jason DeVoss & Robert H. Soriano & Ta, 2014. "NRROS negatively regulates reactive oxygen species during host defence and autoimmunity," Nature, Nature, vol. 509(7499), pages 235-239, May.
    • Handle: RePEc:nat:nature:v:509:y:2014:i:7499:d:10.1038_nature13152
    DOI: 10.1038/nature13152
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    Cited by:

    1. Nicolas Denans & Nhung T. T. Tran & Madeleine E. Swall & Daniel C. Diaz & Jillian Blanck & Tatjana Piotrowski, 2022. "An anti-inflammatory activation sequence governs macrophage transcriptional dynamics during tissue injury in zebrafish," Nature Communications, Nature, vol. 13(1), pages 1-15, December.

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