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Endosomes are specialized platforms for bacterial sensing and NOD2 signalling

Author

Listed:
  • Norihiro Nakamura

    (Genentech, 1 DNA Way)

  • Jennie R. Lill

    (Genentech, 1 DNA Way)

  • Qui Phung

    (Genentech, 1 DNA Way)

  • Zhaoshi Jiang

    (Genentech, 1 DNA Way)

  • Corey Bakalarski

    (Genentech, 1 DNA Way)

  • Ann de Mazière

    (University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands)

  • Judith Klumperman

    (University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands)

  • Megan Schlatter

    (Genentech, 1 DNA Way)

  • Lélia Delamarre

    (Genentech, 1 DNA Way)

  • Ira Mellman

    (Genentech, 1 DNA Way)

Abstract

The endo-lysosomal transporters SLC15A3 and SLC15A4 provide a portal of entry for extracellular bacterial products that activate the cytoplasmic sensor NOD2; these results establish the importance of endosomes as signalling platforms specialized for triggering innate immune responses.

Suggested Citation

  • Norihiro Nakamura & Jennie R. Lill & Qui Phung & Zhaoshi Jiang & Corey Bakalarski & Ann de Mazière & Judith Klumperman & Megan Schlatter & Lélia Delamarre & Ira Mellman, 2014. "Endosomes are specialized platforms for bacterial sensing and NOD2 signalling," Nature, Nature, vol. 509(7499), pages 240-244, May.
    • Handle: RePEc:nat:nature:v:509:y:2014:i:7499:d:10.1038_nature13133
    DOI: 10.1038/nature13133
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    Cited by:

    1. Pei Ying Ng & Amy B. P. Ribet & Qiang Guo & Benjamin H. Mullin & Jamie W. Y. Tan & Euphemie Landao-Bassonga & Sébastien Stephens & Kai Chen & Jinbo Yuan & Laila Abudulai & Maike Bollen & Edward T. T. , 2023. "Sugar transporter Slc37a2 regulates bone metabolism in mice via a tubular lysosomal network in osteoclasts," Nature Communications, Nature, vol. 14(1), pages 1-23, December.
    2. Tânia F. Custódio & Maxime Killer & Dingquan Yu & Virginia Puente & Daniel P. Teufel & Alexander Pautsch & Gisela Schnapp & Marc Grundl & Jan Kosinski & Christian Löw, 2023. "Molecular basis of TASL recruitment by the peptide/histidine transporter 1, PHT1," Nature Communications, Nature, vol. 14(1), pages 1-12, December.

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