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Identification of genomic alterations in oesophageal squamous cell cancer

Author

Listed:
  • Yongmei Song

    (State Key Laboratory of Molecular Oncology, Cancer Institute and Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College)

  • Lin Li

    (BGI-Shenzhen)

  • Yunwei Ou

    (State Key Laboratory of Molecular Oncology, Cancer Institute and Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
    Chinese PLA General Hospital, Beijing 100853, China)

  • Zhibo Gao

    (BGI-Shenzhen)

  • Enmin Li

    (The Key Laboratory of Molecular Biology for High Cancer Incidence Coastal Chaoshan Area, Shantou University Medical College, Shantou 515041, Guangdong, China)

  • Xiangchun Li

    (BGI-Shenzhen)

  • Weimin Zhang

    (State Key Laboratory of Molecular Oncology, Cancer Institute and Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College)

  • Jiaqian Wang

    (BGI-Shenzhen)

  • Liyan Xu

    (Institute of Oncologic Pathology, Shantou University Medical College, Shantou 515041, Guangdong, China)

  • Yong Zhou

    (BGI-Shenzhen)

  • Xiaojuan Ma

    (State Key Laboratory of Molecular Oncology, Cancer Institute and Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College)

  • Lingyan Liu

    (State Key Laboratory of Molecular Oncology, Cancer Institute and Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College)

  • Zitong Zhao

    (State Key Laboratory of Molecular Oncology, Cancer Institute and Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College)

  • Xuanlin Huang

    (BGI-Shenzhen)

  • Jing Fan

    (State Key Laboratory of Molecular Oncology, Cancer Institute and Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College)

  • Lijia Dong

    (State Key Laboratory of Molecular Oncology, Cancer Institute and Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College)

  • Gang Chen

    (BGI-Shenzhen)

  • Liying Ma

    (State Key Laboratory of Molecular Oncology, Cancer Institute and Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College)

  • Jie Yang

    (BGI-Shenzhen)

  • Longyun Chen

    (BGI-Shenzhen)

  • Minghui He

    (BGI-Shenzhen)

  • Miao Li

    (BGI-Shenzhen)

  • Xuehan Zhuang

    (BGI-Shenzhen)

  • Kai Huang

    (BGI-Shenzhen)

  • Kunlong Qiu

    (BGI-Shenzhen)

  • Guangliang Yin

    (BGI-Shenzhen)

  • Guangwu Guo

    (BGI-Shenzhen)

  • Qiang Feng

    (BGI-Shenzhen)

  • Peishan Chen

    (BGI-Shenzhen)

  • Zhiyong Wu

    (Shantou Central Hospital, Affiliated Shantou Hospital of Sun Yat-sen University, Shantou 515041, Guangdong, China)

  • Jianyi Wu

    (The Key Laboratory of Molecular Biology for High Cancer Incidence Coastal Chaoshan Area, Shantou University Medical College, Shantou 515041, Guangdong, China)

  • Ling Ma

    (State Key Laboratory of Molecular Oncology, Cancer Institute and Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College)

  • Jinyang Zhao

    (BGI-Shenzhen)

  • Longhai Luo

    (BGI-Shenzhen)

  • Ming Fu

    (State Key Laboratory of Molecular Oncology, Cancer Institute and Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College)

  • Bainan Xu

    (Chinese PLA General Hospital, Beijing 100853, China)

  • Bo Chen

    (Institute of Oncologic Pathology, Shantou University Medical College, Shantou 515041, Guangdong, China)

  • Yingrui Li

    (BGI-Shenzhen)

  • Tong Tong

    (State Key Laboratory of Molecular Oncology, Cancer Institute and Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College)

  • Mingrong Wang

    (State Key Laboratory of Molecular Oncology, Cancer Institute and Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College)

  • Zhihua Liu

    (State Key Laboratory of Molecular Oncology, Cancer Institute and Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College)

  • Dongxin Lin

    (State Key Laboratory of Molecular Oncology, Cancer Institute and Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College)

  • Xiuqing Zhang

    (BGI-Shenzhen)

  • Huanming Yang

    (BGI-Shenzhen)

  • Jun Wang

    (BGI-Shenzhen)

  • Qimin Zhan

    (State Key Laboratory of Molecular Oncology, Cancer Institute and Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College)

Abstract

Using whole-genome and whole-exome sequencing, this study identifies eight significantly mutated genes in oesophageal squamous cell cancer, including two genes, ADAM29 and FAM135B, not previously associated with this cancer type.

Suggested Citation

  • Yongmei Song & Lin Li & Yunwei Ou & Zhibo Gao & Enmin Li & Xiangchun Li & Weimin Zhang & Jiaqian Wang & Liyan Xu & Yong Zhou & Xiaojuan Ma & Lingyan Liu & Zitong Zhao & Xuanlin Huang & Jing Fan & Liji, 2014. "Identification of genomic alterations in oesophageal squamous cell cancer," Nature, Nature, vol. 509(7498), pages 91-95, May.
    • Handle: RePEc:nat:nature:v:509:y:2014:i:7498:d:10.1038_nature13176
    DOI: 10.1038/nature13176
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    Citations

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    Cited by:

    1. Guozhong Jiang & Zhizhong Wang & Zhenguo Cheng & Weiwei Wang & Shuangshuang Lu & Zifang Zhang & Chinedu A. Anene & Faraz Khan & Yue Chen & Emma Bailey & Huisha Xu & Yunshu Dong & Peinan Chen & Zhongxi, 2024. "The integrated molecular and histological analysis defines subtypes of esophageal squamous cell carcinoma," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    2. Sijia Cui & Nicholas McGranahan & Jing Gao & Peng Chen & Wei Jiang & Lingrong Yang & Li Ma & Junfang Liao & Tian Xie & Congying Xie & Tariq Enver & Shixiu Wu, 2023. "Tracking the evolution of esophageal squamous cell carcinoma under dynamic immune selection by multi-omics sequencing," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    3. Lingling Li & Dongxian Jiang & Qiao Zhang & Hui Liu & Fujiang Xu & Chunmei Guo & Zhaoyu Qin & Haixing Wang & Jinwen Feng & Yang Liu & Weijie Chen & Xue Zhang & Lin Bai & Sha Tian & Subei Tan & Chen Xu, 2023. "Integrative proteogenomic characterization of early esophageal cancer," Nature Communications, Nature, vol. 14(1), pages 1-28, December.
    4. Haidi Huang & Yu Jiang & Jiangying Liu & Dan Luo & Jianghong Yuan & Rongzi Mu & Xiang Yu & Donglei Sun & Jihong Lin & Qiyue Chen & Xinjing Li & Ming Jiang & Jianming Xu & Bo Chu & Chengqian Yin & Lei , 2024. "Jag1/2 maintain esophageal homeostasis and suppress foregut tumorigenesis by restricting the basal progenitor cell pool," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    5. Minghao Li & Zicheng Zhang & Qianrong Wang & Yan Yi & Baosheng Li, 2022. "Integrated cohort of esophageal squamous cell cancer reveals genomic features underlying clinical characteristics," Nature Communications, Nature, vol. 13(1), pages 1-15, December.

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