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Structural basis for ubiquitin-mediated antiviral signal activation by RIG-I

Author

Listed:
  • Alys Peisley

    (Harvard Medical School
    Program in Cellular and Molecular Medicine, Children’s Hospital Boston)

  • Bin Wu

    (Harvard Medical School
    Program in Cellular and Molecular Medicine, Children’s Hospital Boston)

  • Hui Xu

    (University of Texas Southwestern Medical Center)

  • Zhijian J. Chen

    (University of Texas Southwestern Medical Center
    Howard Hughes Medical Institute)

  • Sun Hur

    (Harvard Medical School
    Program in Cellular and Molecular Medicine, Children’s Hospital Boston)

Abstract

RIG-I protein recognizes viral duplex RNA with a 5′-triphosphate group, activating innate immune responses; a crystal structure of its tetrameric CARD signalling domain reveals that non-covalently linked ubiquitin chains stabilize the tetramer in a ‘lock-washer’ structure that serves as a signalling platform for the recruitment and activation of MAVS.

Suggested Citation

  • Alys Peisley & Bin Wu & Hui Xu & Zhijian J. Chen & Sun Hur, 2014. "Structural basis for ubiquitin-mediated antiviral signal activation by RIG-I," Nature, Nature, vol. 509(7498), pages 110-114, May.
    • Handle: RePEc:nat:nature:v:509:y:2014:i:7498:d:10.1038_nature13140
    DOI: 10.1038/nature13140
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    Cited by:

    1. Jiaxin Li & Rui Zhang & Changwan Wang & Junyan Zhu & Miao Ren & Yingbo Jiang & Xianteng Hou & Yangting Du & Qing Wu & Shishi Qi & Lin Li & She Chen & Hui Yang & Fajian Hou, 2023. "WDR77 inhibits prion-like aggregation of MAVS to limit antiviral innate immune response," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    2. Frank Herkules & Corey H. Yu & Alexander B. Taylor & Vi Dougherty & Susan T. Weintraub & Dmitri N. Ivanov, 2022. "Structural and functional asymmetry of RING trimerization controls priming and extension events in TRIM5α autoubiquitylation," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    3. Bryan Korithoski & Oralia Kolaczkowski & Krishanu Mukherjee & Reema Kola & Chandra Earl & Bryan Kolaczkowski, 2015. "Evolution of a Novel Antiviral Immune-Signaling Interaction by Partial-Gene Duplication," PLOS ONE, Public Library of Science, vol. 10(9), pages 1-26, September.
    4. Wenshuai Wang & Benjamin Götte & Rong Guo & Anna Marie Pyle, 2023. "The E3 ligase Riplet promotes RIG-I signaling independent of RIG-I oligomerization," Nature Communications, Nature, vol. 14(1), pages 1-13, December.

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