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Trogocytosis by Entamoeba histolytica contributes to cell killing and tissue invasion

Author

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  • Katherine S. Ralston

    (University of Virginia)

  • Michael D. Solga

    (Immunology and Cancer Biology, University of Virginia)

  • Nicole M. Mackey-Lawrence

    (University of Virginia)

  • Somlata

    (School of Life Sciences, Jawaharlal Nehru University, 110067 New Delhi, India)

  • Alok Bhattacharya

    (School of Life Sciences, Jawaharlal Nehru University, 110067 New Delhi, India)

  • William A. Petri

    (University of Virginia
    Immunology and Cancer Biology, University of Virginia
    University of Virginia)

Abstract

Entamoeba histolytica, the causative agent of fatal diarrhoeal disease in children in the developing world, is shown here to kill human cells by biting off and ingesting pieces of cells, in a process reminiscent of the trogocytosis seen between immune cells; ingestion of bites is required for killing and this mechanism is used both in tissue culture and during invasion of intestinal explants.

Suggested Citation

  • Katherine S. Ralston & Michael D. Solga & Nicole M. Mackey-Lawrence & Somlata & Alok Bhattacharya & William A. Petri, 2014. "Trogocytosis by Entamoeba histolytica contributes to cell killing and tissue invasion," Nature, Nature, vol. 508(7497), pages 526-530, April.
    • Handle: RePEc:nat:nature:v:508:y:2014:i:7497:d:10.1038_nature13242
    DOI: 10.1038/nature13242
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