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Inhibition of miR-25 improves cardiac contractility in the failing heart

Author

Listed:
  • Christine Wahlquist

    (University of California, San Diego, and the Muscle Development and Regeneration Program, Sanford-Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, USA)

  • Dongtak Jeong

    (The Cardiovascular Research Center, Icahn School of Medicine at Mount Sinai)

  • Agustin Rojas-Muñoz

    (University of California, San Diego, and the Muscle Development and Regeneration Program, Sanford-Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, USA)

  • Changwon Kho

    (The Cardiovascular Research Center, Icahn School of Medicine at Mount Sinai)

  • Ahyoung Lee

    (The Cardiovascular Research Center, Icahn School of Medicine at Mount Sinai)

  • Shinichi Mitsuyama

    (The Cardiovascular Research Center, Icahn School of Medicine at Mount Sinai)

  • Alain van Mil

    (University of California, San Diego, and the Muscle Development and Regeneration Program, Sanford-Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, USA
    University Medical Center Utrecht and ICIN Netherlands Heart Institute, Heidelberglaan 100, room G02.523, 3584 CX Utrecht, The Netherlands)

  • Woo Jin Park

    (Global Research Laboratory, Gwangju Institute of Science and Technology, 123 Cheomdan-gwagiro, Buk-gu, Gwangju 500-712, South Korea)

  • Joost P. G. Sluijter

    (University Medical Center Utrecht and ICIN Netherlands Heart Institute, Heidelberglaan 100, room G02.523, 3584 CX Utrecht, The Netherlands)

  • Pieter A. F. Doevendans

    (University Medical Center Utrecht and ICIN Netherlands Heart Institute, Heidelberglaan 100, room G02.523, 3584 CX Utrecht, The Netherlands)

  • Roger J. Hajjar

    (The Cardiovascular Research Center, Icahn School of Medicine at Mount Sinai)

  • Mark Mercola

    (University of California, San Diego, and the Muscle Development and Regeneration Program, Sanford-Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, USA)

Abstract

Reduced activity of the calcium-transporting ATPase SERCA2a is a hallmark of heart failure; here, microRNAs that downregulate SERCA2a function are identified, and antagonism of one, miR-25, is shown to halt heart failure in mice.

Suggested Citation

  • Christine Wahlquist & Dongtak Jeong & Agustin Rojas-Muñoz & Changwon Kho & Ahyoung Lee & Shinichi Mitsuyama & Alain van Mil & Woo Jin Park & Joost P. G. Sluijter & Pieter A. F. Doevendans & Roger J. H, 2014. "Inhibition of miR-25 improves cardiac contractility in the failing heart," Nature, Nature, vol. 508(7497), pages 531-535, April.
    • Handle: RePEc:nat:nature:v:508:y:2014:i:7497:d:10.1038_nature13073
    DOI: 10.1038/nature13073
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