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Rapid and tunable post-translational coupling of genetic circuits

Author

Listed:
  • Arthur Prindle

    (University of California, San Diego, La Jolla, California 92093, USA)

  • Jangir Selimkhanov

    (University of California, San Diego, La Jolla, California 92093, USA)

  • Howard Li

    (University of California, San Diego, La Jolla, California 92093, USA)

  • Ivan Razinkov

    (University of California, San Diego, La Jolla, California 92093, USA)

  • Lev S. Tsimring

    (BioCircuits Institute, University of California, San Diego, La Jolla, California 92093, USA)

  • Jeff Hasty

    (University of California, San Diego, La Jolla, California 92093, USA
    BioCircuits Institute, University of California, San Diego, La Jolla, California 92093, USA
    Molecular Biology Section, University of California, San Diego, La Jolla, California 92093, USA)

Abstract

Protease competition is used to produce rapid and tunable coupling of genetic circuits, enabling a coupled clock network that can encode independent environmental cues into a single time series output, a form of frequency multiplexing in a genetic circuit context.

Suggested Citation

  • Arthur Prindle & Jangir Selimkhanov & Howard Li & Ivan Razinkov & Lev S. Tsimring & Jeff Hasty, 2014. "Rapid and tunable post-translational coupling of genetic circuits," Nature, Nature, vol. 508(7496), pages 387-391, April.
    • Handle: RePEc:nat:nature:v:508:y:2014:i:7496:d:10.1038_nature13238
    DOI: 10.1038/nature13238
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    Cited by:

    1. Yuanli Gao & Lei Wang & Baojun Wang, 2023. "Customizing cellular signal processing by synthetic multi-level regulatory circuits," Nature Communications, Nature, vol. 14(1), pages 1-14, December.

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