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Direct measurement of local oxygen concentration in the bone marrow of live animals

Author

Listed:
  • Joel A. Spencer

    (Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School
    Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School
    Tufts University)

  • Francesca Ferraro

    (Center for Regenerative Medicine, Massachusetts General Hospital, Harvard Medical School
    Harvard Stem Cell Institute
    Harvard University)

  • Emmanuel Roussakis

    (Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School
    University of Pennsylvania)

  • Alyssa Klein

    (Center for Regenerative Medicine, Massachusetts General Hospital, Harvard Medical School
    Harvard Stem Cell Institute
    Harvard University)

  • Juwell Wu

    (Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School
    Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School)

  • Judith M. Runnels

    (Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School
    Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School)

  • Walid Zaher

    (Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School
    Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School
    Stem Cell Unit, College of Medicine, King Saud University, Riyadh 11461, Saudi Arabia)

  • Luke J. Mortensen

    (Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School
    Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School)

  • Clemens Alt

    (Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School
    Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School)

  • Raphaël Turcotte

    (Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School
    Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School
    Boston University)

  • Rushdia Yusuf

    (Center for Regenerative Medicine, Massachusetts General Hospital, Harvard Medical School
    Harvard Stem Cell Institute
    Harvard University)

  • Daniel Côté

    (Génie Physique et Optique and Centre de Recherche de l’Institut Universitaire en Santé Mentale de Québec, Université Laval, Québec City, Québec G1J 2G3, Canada)

  • Sergei A. Vinogradov

    (University of Pennsylvania)

  • David T. Scadden

    (Center for Regenerative Medicine, Massachusetts General Hospital, Harvard Medical School
    Harvard Stem Cell Institute
    Harvard University)

  • Charles P. Lin

    (Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School
    Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School
    Harvard Stem Cell Institute)

Abstract

Here, using two-photon phosphorescence lifetime microscopy, the local oxygen tension in the bone marrow of live mice is found to be quite low, with spatiotemporal variations depending on the blood vessel type, distance to the endosteum, and changes in cellularity after stress.

Suggested Citation

  • Joel A. Spencer & Francesca Ferraro & Emmanuel Roussakis & Alyssa Klein & Juwell Wu & Judith M. Runnels & Walid Zaher & Luke J. Mortensen & Clemens Alt & Raphaël Turcotte & Rushdia Yusuf & Daniel Côté, 2014. "Direct measurement of local oxygen concentration in the bone marrow of live animals," Nature, Nature, vol. 508(7495), pages 269-273, April.
    • Handle: RePEc:nat:nature:v:508:y:2014:i:7495:d:10.1038_nature13034
    DOI: 10.1038/nature13034
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    Cited by:

    1. Daniel C. Souza & Nicolas Hebert & Erica B. Esrick & M. Felicia Ciuculescu & Natasha M. Archer & Myriam Armant & Étienne Audureau & Christian Brendel & Giuseppe Caprio & Frédéric Galactéros & Donghui , 2023. "Genetic reversal of the globin switch concurrently modulates both fetal and sickle hemoglobin and reduces red cell sickling," Nature Communications, Nature, vol. 14(1), pages 1-10, December.
    2. Alexandra N. Rindone & Xiaonan Liu & Stephanie Farhat & Alexander Perdomo-Pantoja & Timothy F. Witham & Daniel L. Coutu & Mei Wan & Warren L. Grayson, 2021. "Quantitative 3D imaging of the cranial microvascular environment at single-cell resolution," Nature Communications, Nature, vol. 12(1), pages 1-13, December.
    3. Jianping Wang & Bin Zhao & Jingmin Che & Peng Shang, 2023. "Hypoxia Pathway in Osteoporosis: Laboratory Data for Clinical Prospects," IJERPH, MDPI, vol. 20(4), pages 1-22, February.

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