IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v508y2014i7495d10.1038_nature13005.html
   My bibliography  Save this article

RETRACTED ARTICLE: Detection and replication of epistasis influencing transcription in humans

Author

Listed:
  • Gibran Hemani

    (Queensland Brain Institute, University of Queensland
    University of Queensland Diamantina Institute, University of Queensland, Princess Alexandra Hospital)

  • Konstantin Shakhbazov

    (Queensland Brain Institute, University of Queensland
    University of Queensland Diamantina Institute, University of Queensland, Princess Alexandra Hospital)

  • Harm-Jan Westra

    (University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9700 RB Groningen, The Netherlands)

  • Tonu Esko

    (Estonian Genome Center, University of Tartu, Tartu 51010, Estonia
    Medical and Population Genetics, Broad Institute
    Children's Hospital)

  • Anjali K. Henders

    (Queensland Institute of Medical Research)

  • Allan F. McRae

    (Queensland Brain Institute, University of Queensland
    University of Queensland Diamantina Institute, University of Queensland, Princess Alexandra Hospital)

  • Jian Yang

    (Queensland Brain Institute, University of Queensland)

  • Greg Gibson

    (School of Biology and Centre for Integrative Genomics, Georgia Institute of Technology)

  • Nicholas G. Martin

    (Queensland Institute of Medical Research)

  • Andres Metspalu

    (Estonian Genome Center, University of Tartu, Tartu 51010, Estonia)

  • Lude Franke

    (University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9700 RB Groningen, The Netherlands)

  • Grant W. Montgomery

    (Queensland Institute of Medical Research)

  • Peter M. Visscher

    (Queensland Brain Institute, University of Queensland
    University of Queensland Diamantina Institute, University of Queensland, Princess Alexandra Hospital)

  • Joseph E. Powell

    (Queensland Brain Institute, University of Queensland
    University of Queensland Diamantina Institute, University of Queensland, Princess Alexandra Hospital)

Abstract

Epistasis has rarely been shown among natural polymorphisms in human traits; this research using advanced computation and gene expression data reveals many instances of epistasis between common single nucleotide polymorphisms in humans, with epistasis and the direction of its effect replicating in independent cohorts.

Suggested Citation

  • Gibran Hemani & Konstantin Shakhbazov & Harm-Jan Westra & Tonu Esko & Anjali K. Henders & Allan F. McRae & Jian Yang & Greg Gibson & Nicholas G. Martin & Andres Metspalu & Lude Franke & Grant W. Montg, 2014. "RETRACTED ARTICLE: Detection and replication of epistasis influencing transcription in humans," Nature, Nature, vol. 508(7495), pages 249-253, April.
    • Handle: RePEc:nat:nature:v:508:y:2014:i:7495:d:10.1038_nature13005
    DOI: 10.1038/nature13005
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature13005
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature13005?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:508:y:2014:i:7495:d:10.1038_nature13005. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.