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Mouse liver repopulation with hepatocytes generated from human fibroblasts

Author

Listed:
  • Saiyong Zhu

    (Gladstone Institute of Cardiovascular Disease, 1650 Owens Street)

  • Milad Rezvani

    (Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California San Francisco, 35 Medical Center Way)

  • Jack Harbell

    (University of California San Francisco, 505 Parnassus Avenue, San Francisco, California 94143, USA)

  • Aras N. Mattis

    (Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California San Francisco, 35 Medical Center Way
    Liver Center, University of California San Francisco, 1001 Potrero Avenue, San Francisco, California 94110, USA
    University of California San Francisco, 505 Parnassus Avenue, San Francisco, California 94143, USA)

  • Alan R. Wolfe

    (University of California San Francisco, 533 Parnassus Avenue, San Francisco, California 94143, USA)

  • Leslie Z. Benet

    (University of California San Francisco, 533 Parnassus Avenue, San Francisco, California 94143, USA)

  • Holger Willenbring

    (Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California San Francisco, 35 Medical Center Way
    University of California San Francisco, 505 Parnassus Avenue, San Francisco, California 94143, USA
    Liver Center, University of California San Francisco, 1001 Potrero Avenue, San Francisco, California 94110, USA)

  • Sheng Ding

    (Gladstone Institute of Cardiovascular Disease, 1650 Owens Street
    University of California San Francisco, 600 16th Street, San Francisco, California 94158, USA)

Abstract

Human fibroblasts can be converted into hepatocytes capable of repopulating mouse livers by shortcutting reprogramming to pluripotency with factors promoting endoderm and hepatocyte differentiation.

Suggested Citation

  • Saiyong Zhu & Milad Rezvani & Jack Harbell & Aras N. Mattis & Alan R. Wolfe & Leslie Z. Benet & Holger Willenbring & Sheng Ding, 2014. "Mouse liver repopulation with hepatocytes generated from human fibroblasts," Nature, Nature, vol. 508(7494), pages 93-97, April.
    • Handle: RePEc:nat:nature:v:508:y:2014:i:7494:d:10.1038_nature13020
    DOI: 10.1038/nature13020
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