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The E3 ligase Cbl-b and TAM receptors regulate cancer metastasis via natural killer cells

Author

Listed:
  • Magdalena Paolino

    (IMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences, 1030 Vienna, Austria)

  • Axel Choidas

    (Lead Discovery Center GmbH, D-44227 Dortmund, Germany)

  • Stephanie Wallner

    (Medical University Innsbruck, 6020 Innsbruck, Austria)

  • Blanka Pranjic

    (IMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences, 1030 Vienna, Austria)

  • Iris Uribesalgo

    (IMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences, 1030 Vienna, Austria)

  • Stefanie Loeser

    (IMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences, 1030 Vienna, Austria)

  • Amanda M. Jamieson

    (Brown University)

  • Wallace Y. Langdon

    (School of Pathology and Laboratory Medicine, University of Western Australia, Crawley, Western Australia 6009, Perth, Australia)

  • Fumiyo Ikeda

    (IMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences, 1030 Vienna, Austria)

  • Juan Pablo Fededa

    (IMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences, 1030 Vienna, Austria)

  • Shane J. Cronin

    (IMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences, 1030 Vienna, Austria)

  • Roberto Nitsch

    (IMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences, 1030 Vienna, Austria)

  • Carsten Schultz-Fademrecht

    (Lead Discovery Center GmbH, D-44227 Dortmund, Germany)

  • Jan Eickhoff

    (Lead Discovery Center GmbH, D-44227 Dortmund, Germany)

  • Sascha Menninger

    (Lead Discovery Center GmbH, D-44227 Dortmund, Germany)

  • Anke Unger

    (Lead Discovery Center GmbH, D-44227 Dortmund, Germany)

  • Robert Torka

    (Max-Planck, Institute for Biochemistry, D-82152 Martinsried, Germany)

  • Thomas Gruber

    (Medical University Innsbruck, 6020 Innsbruck, Austria)

  • Reinhard Hinterleitner

    (Medical University Innsbruck, 6020 Innsbruck, Austria)

  • Gottfried Baier

    (Medical University Innsbruck, 6020 Innsbruck, Austria)

  • Dominik Wolf

    (Medical University Innsbruck, 6020 Innsbruck, Austria
    Internal Medicine III, University Hospital Bonn, 53127 Bonn, Germany)

  • Axel Ullrich

    (Max-Planck, Institute for Biochemistry, D-82152 Martinsried, Germany)

  • Bert M. Klebl

    (Lead Discovery Center GmbH, D-44227 Dortmund, Germany)

  • Josef M. Penninger

    (IMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences, 1030 Vienna, Austria)

Abstract

The E3 ligase Cbl-b acts on TAM tyrosine kinase receptors and has a critical role in the regulation of natural killer (NK) cell rejection of metastatic tumours; a small molecule TAM kinase inhibitor is shown to enhance the anti-metastatic NK cell activity.

Suggested Citation

  • Magdalena Paolino & Axel Choidas & Stephanie Wallner & Blanka Pranjic & Iris Uribesalgo & Stefanie Loeser & Amanda M. Jamieson & Wallace Y. Langdon & Fumiyo Ikeda & Juan Pablo Fededa & Shane J. Cronin, 2014. "The E3 ligase Cbl-b and TAM receptors regulate cancer metastasis via natural killer cells," Nature, Nature, vol. 507(7493), pages 508-512, March.
    • Handle: RePEc:nat:nature:v:507:y:2014:i:7493:d:10.1038_nature12998
    DOI: 10.1038/nature12998
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    Cited by:

    1. David Ascheid & Magdalena Baumann & Jürgen Pinnecker & Mike Friedrich & Daniel Szi-Marton & Cornelia Medved & Maja Bundalo & Vanessa Ortmann & Asli Öztürk & Rajender Nandigama & Katherina Hemmen & Sül, 2024. "A vascularized breast cancer spheroid platform for the ranked evaluation of tumor microenvironment-targeted drugs by light sheet fluorescence microscopy," Nature Communications, Nature, vol. 15(1), pages 1-23, December.

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