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Transcription factor achaete-scute homologue 2 initiates follicular T-helper-cell development

Author

Listed:
  • Xindong Liu

    (Tsinghua University School of Medicine
    MD Anderson Cancer Center)

  • Xin Chen

    (Tsinghua University School of Medicine)

  • Bo Zhong

    (MD Anderson Cancer Center
    Present addresses: College of Life Sciences, Wuhan University, Wuhan 430072, China (B.Z.); SomantiX B.V., Padualaan 8, 3584 CH Utrecht, the Netherlands (L.G.v.d.F.).)

  • Aibo Wang

    (Tsinghua University School of Medicine
    MD Anderson Cancer Center)

  • Xiaohu Wang

    (Tsinghua University School of Medicine
    MD Anderson Cancer Center)

  • Fuliang Chu

    (MD Anderson Cancer Center)

  • Roza I. Nurieva

    (MD Anderson Cancer Center)

  • Xiaowei Yan

    (Institute for Systems Biology)

  • Ping Chen

    (Laboratory of Immunology, National Eye Institute, NIH, Bethesda, Maryland 20892-1858, USA)

  • Laurens G. van der Flier

    (Hubrecht Institute-KNAW and University Medical Center Utrecht, Uppsalalaan 8, 3584 CT Utrecht, the Netherlands
    Present addresses: College of Life Sciences, Wuhan University, Wuhan 430072, China (B.Z.); SomantiX B.V., Padualaan 8, 3584 CH Utrecht, the Netherlands (L.G.v.d.F.).)

  • Hiroko Nakatsukasa

    (National Institute of Dental and Craniofacial Research, NIH)

  • Sattva S. Neelapu

    (MD Anderson Cancer Center)

  • Wanjun Chen

    (National Institute of Dental and Craniofacial Research, NIH)

  • Hans Clevers

    (Hubrecht Institute-KNAW and University Medical Center Utrecht, Uppsalalaan 8, 3584 CT Utrecht, the Netherlands)

  • Qiang Tian

    (Institute for Systems Biology)

  • Hai Qi

    (Tsinghua University School of Medicine)

  • Lai Wei

    (State Key Laboratory of Ophthalmology, Sun Yat-sen University)

  • Chen Dong

    (Tsinghua University School of Medicine
    MD Anderson Cancer Center)

Abstract

Here, the helix–loop–helix transcription factor Ascl2 is shown to be critically important for the initiation of follicular T-helper-cell development and the germinal centre response.

Suggested Citation

  • Xindong Liu & Xin Chen & Bo Zhong & Aibo Wang & Xiaohu Wang & Fuliang Chu & Roza I. Nurieva & Xiaowei Yan & Ping Chen & Laurens G. van der Flier & Hiroko Nakatsukasa & Sattva S. Neelapu & Wanjun Chen , 2014. "Transcription factor achaete-scute homologue 2 initiates follicular T-helper-cell development," Nature, Nature, vol. 507(7493), pages 513-518, March.
    • Handle: RePEc:nat:nature:v:507:y:2014:i:7493:d:10.1038_nature12910
    DOI: 10.1038/nature12910
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    Cited by:

    1. Ivy K Brown & Nathan Dyjack & Mindy M Miller & Harsha Krovi & Cydney Rios & Rachel Woolaver & Laura Harmacek & Ting-Hui Tu & Brian P O’Connor & Thomas Danhorn & Brian Vestal & Laurent Gapin & Clemenci, 2021. "Single cell analysis of host response to helminth infection reveals the clonal breadth, heterogeneity, and tissue-specific programming of the responding CD4+ T cell repertoire," PLOS Pathogens, Public Library of Science, vol. 17(6), pages 1-34, June.
    2. Fangming Zhu & Ryan J. McMonigle & Andrew R. Schroeder & Xianyou Xia & David Figge & Braxton D. Greer & Edahí González-Avalos & Diego O. Sialer & Yin-Hu Wang & Kelly M. Chandler & Adam J. Getzler & Em, 2023. "Spatiotemporal resolution of germinal center Tfh cell differentiation and divergence from central memory CD4+ T cell fate," Nature Communications, Nature, vol. 14(1), pages 1-15, December.

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