IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v507y2014i7492d10.1038_nature12979.html
   My bibliography  Save this article

IL-35-producing B cells are critical regulators of immunity during autoimmune and infectious diseases

Author

Listed:
  • Ping Shen

    (Deutsches Rheuma-Forschungszentrum, a Leibniz Institute, Charitéplatz 1, 10117 Berlin, Germany)

  • Toralf Roch

    (Deutsches Rheuma-Forschungszentrum, a Leibniz Institute, Charitéplatz 1, 10117 Berlin, Germany
    Present address: Institute of Biomaterial Science, Helmholtz-Zentrum Geesthacht, Centre for Materials and Coastal Research, Kantstraße 55, 14513 Teltow, Germany.)

  • Vicky Lampropoulou

    (Deutsches Rheuma-Forschungszentrum, a Leibniz Institute, Charitéplatz 1, 10117 Berlin, Germany)

  • Richard A. O’Connor

    (University of Edinburgh, Centre for Inflammation Research and Centre for Multiple Sclerosis Research, Queen’s Medical Research Institute, Edinburgh EH16 4TJ, UK)

  • Ulrik Stervbo

    (Deutsches Rheuma-Forschungszentrum, a Leibniz Institute, Charitéplatz 1, 10117 Berlin, Germany)

  • Ellen Hilgenberg

    (Deutsches Rheuma-Forschungszentrum, a Leibniz Institute, Charitéplatz 1, 10117 Berlin, Germany)

  • Stefanie Ries

    (Deutsches Rheuma-Forschungszentrum, a Leibniz Institute, Charitéplatz 1, 10117 Berlin, Germany)

  • Van Duc Dang

    (Deutsches Rheuma-Forschungszentrum, a Leibniz Institute, Charitéplatz 1, 10117 Berlin, Germany)

  • Yarúa Jaimes

    (Deutsches Rheuma-Forschungszentrum, a Leibniz Institute, Charitéplatz 1, 10117 Berlin, Germany)

  • Capucine Daridon

    (Deutsches Rheuma-Forschungszentrum, a Leibniz Institute, Charitéplatz 1, 10117 Berlin, Germany
    Charité Universitätsmedizin Berlin, CC12, 10117 Berlin, Germany)

  • Rui Li

    (Neuroimmunology Unit, Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec H3A2B4, Canada)

  • Luc Jouneau

    (Virologie et Immunologie Moléculaires, INRA, 78352 Jouy-en-Josas, France)

  • Pierre Boudinot

    (Virologie et Immunologie Moléculaires, INRA, 78352 Jouy-en-Josas, France)

  • Siska Wilantri

    (Deutsches Rheuma-Forschungszentrum, a Leibniz Institute, Charitéplatz 1, 10117 Berlin, Germany)

  • Imme Sakwa

    (Deutsches Rheuma-Forschungszentrum, a Leibniz Institute, Charitéplatz 1, 10117 Berlin, Germany)

  • Yusei Miyazaki

    (Neuroimmunology Unit, Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec H3A2B4, Canada)

  • Melanie D. Leech

    (University of Edinburgh, Centre for Inflammation Research and Centre for Multiple Sclerosis Research, Queen’s Medical Research Institute, Edinburgh EH16 4TJ, UK)

  • Rhoanne C. McPherson

    (University of Edinburgh, Centre for Inflammation Research and Centre for Multiple Sclerosis Research, Queen’s Medical Research Institute, Edinburgh EH16 4TJ, UK)

  • Stefan Wirtz

    (Medical Clinic 1, Kussmaul Campus for Medical Research, University of Erlangen-Nürnberg, 91054 Erlangen, Germany)

  • Markus Neurath

    (Medical Clinic 1, Kussmaul Campus for Medical Research, University of Erlangen-Nürnberg, 91054 Erlangen, Germany)

  • Kai Hoehlig

    (Deutsches Rheuma-Forschungszentrum, a Leibniz Institute, Charitéplatz 1, 10117 Berlin, Germany)

  • Edgar Meinl

    (Institut für Klinische Neuroimmunologie Klinikum der Ludwig-Maximilians-Universität München, 81377 München, Germany)

  • Andreas Grützkau

    (Deutsches Rheuma-Forschungszentrum, a Leibniz Institute, Charitéplatz 1, 10117 Berlin, Germany)

  • Joachim R. Grün

    (Deutsches Rheuma-Forschungszentrum, a Leibniz Institute, Charitéplatz 1, 10117 Berlin, Germany)

  • Katharina Horn

    (Deutsches Rheuma-Forschungszentrum, a Leibniz Institute, Charitéplatz 1, 10117 Berlin, Germany)

  • Anja A. Kühl

    (Immunpathologie, Research Center ImmunoSciences, 12203 Berlin, Germany)

  • Thomas Dörner

    (Deutsches Rheuma-Forschungszentrum, a Leibniz Institute, Charitéplatz 1, 10117 Berlin, Germany
    Charité Universitätsmedizin Berlin, CC12, 10117 Berlin, Germany)

  • Amit Bar-Or

    (Neuroimmunology Unit, Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec H3A2B4, Canada)

  • Stefan H. E. Kaufmann

    (Max Planck Institute of Infection Biology, Charitéplatz 1, 10117 Berlin, Germany)

  • Stephen M. Anderton

    (University of Edinburgh, Centre for Inflammation Research and Centre for Multiple Sclerosis Research, Queen’s Medical Research Institute, Edinburgh EH16 4TJ, UK)

  • Simon Fillatreau

    (Deutsches Rheuma-Forschungszentrum, a Leibniz Institute, Charitéplatz 1, 10117 Berlin, Germany)

Abstract

B cells can secrete IL-35 upon activation, and subsequently contribute negatively to the regulation of immunity, such as T-cell-mediated autoimmunity or anti-microbial immunity, and a characterization of these cells raises new questions about possible independent roles for IL-10- and IL-35-expressing plasma cells as regulatory cells.

Suggested Citation

  • Ping Shen & Toralf Roch & Vicky Lampropoulou & Richard A. O’Connor & Ulrik Stervbo & Ellen Hilgenberg & Stefanie Ries & Van Duc Dang & Yarúa Jaimes & Capucine Daridon & Rui Li & Luc Jouneau & Pierre B, 2014. "IL-35-producing B cells are critical regulators of immunity during autoimmune and infectious diseases," Nature, Nature, vol. 507(7492), pages 366-370, March.
    • Handle: RePEc:nat:nature:v:507:y:2014:i:7492:d:10.1038_nature12979
    DOI: 10.1038/nature12979
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature12979
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature12979?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Channakeshava Sokke Umeshappa & Patricia Solé & Jun Yamanouchi & Saswat Mohapatra & Bas G. J. Surewaard & Josep Garnica & Santiswarup Singha & Debajyoti Mondal & Elena Cortés-Vicente & Charlotte D’Mel, 2022. "Re-programming mouse liver-resident invariant natural killer T cells for suppressing hepatic and diabetogenic autoimmunity," Nature Communications, Nature, vol. 13(1), pages 1-19, December.
    2. Akshay J. Patel & Zena N. Willsmore & Naeem Khan & Alex Richter & Babu Naidu & Mark T. Drayson & Sophie Papa & Andrew Cope & Sophia N. Karagiannis & Esperanza Perucha & Gary W. Middleton, 2022. "Regulatory B cell repertoire defects predispose lung cancer patients to immune-related toxicity following checkpoint blockade," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    3. S. Shankar & J. Stolp & S. C. Juvet & J. Beckett & P. S. Macklin & F. Issa & J. Hester & K. J. Wood, 2022. "Ex vivo-expanded human CD19+TIM-1+ regulatory B cells suppress immune responses in vivo and are dependent upon the TIM-1/STAT3 axis," Nature Communications, Nature, vol. 13(1), pages 1-19, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:507:y:2014:i:7492:d:10.1038_nature12979. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.