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IL-35-producing B cells are critical regulators of immunity during autoimmune and infectious diseases

Author

Listed:
  • Ping Shen

    (Deutsches Rheuma-Forschungszentrum, a Leibniz Institute, Charitéplatz 1, 10117 Berlin, Germany)

  • Toralf Roch

    (Deutsches Rheuma-Forschungszentrum, a Leibniz Institute, Charitéplatz 1, 10117 Berlin, Germany
    Present address: Institute of Biomaterial Science, Helmholtz-Zentrum Geesthacht, Centre for Materials and Coastal Research, Kantstraße 55, 14513 Teltow, Germany.)

  • Vicky Lampropoulou

    (Deutsches Rheuma-Forschungszentrum, a Leibniz Institute, Charitéplatz 1, 10117 Berlin, Germany)

  • Richard A. O’Connor

    (University of Edinburgh, Centre for Inflammation Research and Centre for Multiple Sclerosis Research, Queen’s Medical Research Institute, Edinburgh EH16 4TJ, UK)

  • Ulrik Stervbo

    (Deutsches Rheuma-Forschungszentrum, a Leibniz Institute, Charitéplatz 1, 10117 Berlin, Germany)

  • Ellen Hilgenberg

    (Deutsches Rheuma-Forschungszentrum, a Leibniz Institute, Charitéplatz 1, 10117 Berlin, Germany)

  • Stefanie Ries

    (Deutsches Rheuma-Forschungszentrum, a Leibniz Institute, Charitéplatz 1, 10117 Berlin, Germany)

  • Van Duc Dang

    (Deutsches Rheuma-Forschungszentrum, a Leibniz Institute, Charitéplatz 1, 10117 Berlin, Germany)

  • Yarúa Jaimes

    (Deutsches Rheuma-Forschungszentrum, a Leibniz Institute, Charitéplatz 1, 10117 Berlin, Germany)

  • Capucine Daridon

    (Deutsches Rheuma-Forschungszentrum, a Leibniz Institute, Charitéplatz 1, 10117 Berlin, Germany
    Charité Universitätsmedizin Berlin, CC12, 10117 Berlin, Germany)

  • Rui Li

    (Neuroimmunology Unit, Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec H3A2B4, Canada)

  • Luc Jouneau

    (Virologie et Immunologie Moléculaires, INRA, 78352 Jouy-en-Josas, France)

  • Pierre Boudinot

    (Virologie et Immunologie Moléculaires, INRA, 78352 Jouy-en-Josas, France)

  • Siska Wilantri

    (Deutsches Rheuma-Forschungszentrum, a Leibniz Institute, Charitéplatz 1, 10117 Berlin, Germany)

  • Imme Sakwa

    (Deutsches Rheuma-Forschungszentrum, a Leibniz Institute, Charitéplatz 1, 10117 Berlin, Germany)

  • Yusei Miyazaki

    (Neuroimmunology Unit, Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec H3A2B4, Canada)

  • Melanie D. Leech

    (University of Edinburgh, Centre for Inflammation Research and Centre for Multiple Sclerosis Research, Queen’s Medical Research Institute, Edinburgh EH16 4TJ, UK)

  • Rhoanne C. McPherson

    (University of Edinburgh, Centre for Inflammation Research and Centre for Multiple Sclerosis Research, Queen’s Medical Research Institute, Edinburgh EH16 4TJ, UK)

  • Stefan Wirtz

    (Medical Clinic 1, Kussmaul Campus for Medical Research, University of Erlangen-Nürnberg, 91054 Erlangen, Germany)

  • Markus Neurath

    (Medical Clinic 1, Kussmaul Campus for Medical Research, University of Erlangen-Nürnberg, 91054 Erlangen, Germany)

  • Kai Hoehlig

    (Deutsches Rheuma-Forschungszentrum, a Leibniz Institute, Charitéplatz 1, 10117 Berlin, Germany)

  • Edgar Meinl

    (Institut für Klinische Neuroimmunologie Klinikum der Ludwig-Maximilians-Universität München, 81377 München, Germany)

  • Andreas Grützkau

    (Deutsches Rheuma-Forschungszentrum, a Leibniz Institute, Charitéplatz 1, 10117 Berlin, Germany)

  • Joachim R. Grün

    (Deutsches Rheuma-Forschungszentrum, a Leibniz Institute, Charitéplatz 1, 10117 Berlin, Germany)

  • Katharina Horn

    (Deutsches Rheuma-Forschungszentrum, a Leibniz Institute, Charitéplatz 1, 10117 Berlin, Germany)

  • Anja A. Kühl

    (Immunpathologie, Research Center ImmunoSciences, 12203 Berlin, Germany)

  • Thomas Dörner

    (Deutsches Rheuma-Forschungszentrum, a Leibniz Institute, Charitéplatz 1, 10117 Berlin, Germany
    Charité Universitätsmedizin Berlin, CC12, 10117 Berlin, Germany)

  • Amit Bar-Or

    (Neuroimmunology Unit, Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec H3A2B4, Canada)

  • Stefan H. E. Kaufmann

    (Max Planck Institute of Infection Biology, Charitéplatz 1, 10117 Berlin, Germany)

  • Stephen M. Anderton

    (University of Edinburgh, Centre for Inflammation Research and Centre for Multiple Sclerosis Research, Queen’s Medical Research Institute, Edinburgh EH16 4TJ, UK)

  • Simon Fillatreau

    (Deutsches Rheuma-Forschungszentrum, a Leibniz Institute, Charitéplatz 1, 10117 Berlin, Germany)

Abstract

B cells can secrete IL-35 upon activation, and subsequently contribute negatively to the regulation of immunity, such as T-cell-mediated autoimmunity or anti-microbial immunity, and a characterization of these cells raises new questions about possible independent roles for IL-10- and IL-35-expressing plasma cells as regulatory cells.

Suggested Citation

  • Ping Shen & Toralf Roch & Vicky Lampropoulou & Richard A. O’Connor & Ulrik Stervbo & Ellen Hilgenberg & Stefanie Ries & Van Duc Dang & Yarúa Jaimes & Capucine Daridon & Rui Li & Luc Jouneau & Pierre B, 2014. "IL-35-producing B cells are critical regulators of immunity during autoimmune and infectious diseases," Nature, Nature, vol. 507(7492), pages 366-370, March.
    • Handle: RePEc:nat:nature:v:507:y:2014:i:7492:d:10.1038_nature12979
    DOI: 10.1038/nature12979
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    Cited by:

    1. S. Shankar & J. Stolp & S. C. Juvet & J. Beckett & P. S. Macklin & F. Issa & J. Hester & K. J. Wood, 2022. "Ex vivo-expanded human CD19+TIM-1+ regulatory B cells suppress immune responses in vivo and are dependent upon the TIM-1/STAT3 axis," Nature Communications, Nature, vol. 13(1), pages 1-19, December.
    2. Channakeshava Sokke Umeshappa & Patricia Solé & Jun Yamanouchi & Saswat Mohapatra & Bas G. J. Surewaard & Josep Garnica & Santiswarup Singha & Debajyoti Mondal & Elena Cortés-Vicente & Charlotte D’Mel, 2022. "Re-programming mouse liver-resident invariant natural killer T cells for suppressing hepatic and diabetogenic autoimmunity," Nature Communications, Nature, vol. 13(1), pages 1-19, December.
    3. Akshay J. Patel & Zena N. Willsmore & Naeem Khan & Alex Richter & Babu Naidu & Mark T. Drayson & Sophie Papa & Andrew Cope & Sophia N. Karagiannis & Esperanza Perucha & Gary W. Middleton, 2022. "Regulatory B cell repertoire defects predispose lung cancer patients to immune-related toxicity following checkpoint blockade," Nature Communications, Nature, vol. 13(1), pages 1-16, December.

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