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DNA-guided DNA interference by a prokaryotic Argonaute

Author

Listed:
  • Daan C. Swarts

    (Laboratory of Microbiology, Wageningen University, Dreijenplein 10, 6703 HB Wageningen, the Netherlands)

  • Matthijs M. Jore

    (Laboratory of Microbiology, Wageningen University, Dreijenplein 10, 6703 HB Wageningen, the Netherlands)

  • Edze R. Westra

    (Laboratory of Microbiology, Wageningen University, Dreijenplein 10, 6703 HB Wageningen, the Netherlands)

  • Yifan Zhu

    (Laboratory of Microbiology, Wageningen University, Dreijenplein 10, 6703 HB Wageningen, the Netherlands)

  • Jorijn H. Janssen

    (Laboratory of Microbiology, Wageningen University, Dreijenplein 10, 6703 HB Wageningen, the Netherlands)

  • Ambrosius P. Snijders

    (Clare Hall Laboratories, Cancer Research UK, London Research Institute, South Mimms EN6 3LD, UK)

  • Yanli Wang

    (Institute of Biophysics, Chinese Academy of Sciences)

  • Dinshaw J. Patel

    (Structural Biology Program, Memorial Sloan-Kettering Cancer Center)

  • José Berenguer

    (Centro de Biología Molecular Severo Ochoa, UAM-CSIC, Campus de Cantoblanco, 28049 Madrid, Spain)

  • Stan J. J. Brouns

    (Laboratory of Microbiology, Wageningen University, Dreijenplein 10, 6703 HB Wageningen, the Netherlands)

  • John van der Oost

    (Laboratory of Microbiology, Wageningen University, Dreijenplein 10, 6703 HB Wageningen, the Netherlands)

Abstract

Here, Argonaute from the prokaryote Thermus thermophilus is shown to use small DNA guides to interfere directly with invading foreign DNA, rather than being involved in RNA-guided RNA interference, as observed in eukaryotes.

Suggested Citation

  • Daan C. Swarts & Matthijs M. Jore & Edze R. Westra & Yifan Zhu & Jorijn H. Janssen & Ambrosius P. Snijders & Yanli Wang & Dinshaw J. Patel & José Berenguer & Stan J. J. Brouns & John van der Oost, 2014. "DNA-guided DNA interference by a prokaryotic Argonaute," Nature, Nature, vol. 507(7491), pages 258-261, March.
    • Handle: RePEc:nat:nature:v:507:y:2014:i:7491:d:10.1038_nature12971
    DOI: 10.1038/nature12971
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    Cited by:

    1. Xinmi Song & Sheng Lei & Shunhang Liu & Yanqiu Liu & Pan Fu & Zhifeng Zeng & Ke Yang & Yu Chen & Ming Li & Qunxin She & Wenyuan Han, 2023. "Catalytically inactive long prokaryotic Argonaute systems employ distinct effectors to confer immunity via abortive infection," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    2. Bin Yang & Haonan Wang & Jilie Kong & Xueen Fang, 2024. "Long-term monitoring of ultratrace nucleic acids using tetrahedral nanostructure-based NgAgo on wearable microneedles," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    3. Lidiya Lisitskaya & Yeonoh Shin & Aleksei Agapov & Anna Olina & Ekaterina Kropocheva & Sergei Ryazansky & Alexei A. Aravin & Daria Esyunina & Katsuhiko S. Murakami & Andrey Kulbachinskiy, 2022. "Programmable RNA targeting by bacterial Argonaute nucleases with unconventional guide binding and cleavage specificity," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    4. Xiangkai Zhen & Xiaolong Xu & Le Ye & Song Xie & Zhijie Huang & Sheng Yang & Yanhui Wang & Jinyu Li & Feng Long & Songying Ouyang, 2024. "Structural basis of antiphage immunity generated by a prokaryotic Argonaute-associated SPARSA system," Nature Communications, Nature, vol. 15(1), pages 1-13, December.

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