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L-Myc expression by dendritic cells is required for optimal T-cell priming

Author

Listed:
  • Wumesh KC

    (Washington University School of Medicine, 660 S. Euclid Avenue, St Louis, Missouri 63110, USA)

  • Ansuman T. Satpathy

    (Washington University School of Medicine, 660 S. Euclid Avenue, St Louis, Missouri 63110, USA)

  • Aaron S. Rapaport

    (Washington University School of Medicine, 660 S. Euclid Avenue, St Louis, Missouri 63110, USA)

  • Carlos G. Briseño

    (Washington University School of Medicine, 660 S. Euclid Avenue, St Louis, Missouri 63110, USA)

  • Xiaodi Wu

    (Washington University School of Medicine, 660 S. Euclid Avenue, St Louis, Missouri 63110, USA)

  • Jörn C. Albring

    (Hematology and Oncology, University of Muenster, 48149 Muenster, Germany)

  • Emilie V. Russler-Germain

    (Washington University School of Medicine, 660 S. Euclid Avenue, St Louis, Missouri 63110, USA)

  • Nicole M. Kretzer

    (Washington University School of Medicine, 660 S. Euclid Avenue, St Louis, Missouri 63110, USA)

  • Vivek Durai

    (Washington University School of Medicine, 660 S. Euclid Avenue, St Louis, Missouri 63110, USA)

  • Stephen P. Persaud

    (Washington University School of Medicine, 660 S. Euclid Avenue, St Louis, Missouri 63110, USA)

  • Brian T. Edelson

    (Washington University School of Medicine, 660 S. Euclid Avenue, St Louis, Missouri 63110, USA)

  • Jakob Loschko

    (Laboratory of Molecular Immunology, Howard Hughes Medical Institute, The Rockefeller University)

  • Marina Cella

    (Washington University School of Medicine, 660 S. Euclid Avenue, St Louis, Missouri 63110, USA)

  • Paul M. Allen

    (Washington University School of Medicine, 660 S. Euclid Avenue, St Louis, Missouri 63110, USA)

  • Michel C. Nussenzweig

    (Laboratory of Molecular Immunology, Howard Hughes Medical Institute, The Rockefeller University)

  • Marco Colonna

    (Washington University School of Medicine, 660 S. Euclid Avenue, St Louis, Missouri 63110, USA)

  • Barry P. Sleckman

    (Washington University School of Medicine, 660 S. Euclid Avenue, St Louis, Missouri 63110, USA)

  • Theresa L. Murphy

    (Washington University School of Medicine, 660 S. Euclid Avenue, St Louis, Missouri 63110, USA)

  • Kenneth M. Murphy

    (Washington University School of Medicine, 660 S. Euclid Avenue, St Louis, Missouri 63110, USA
    Howard Hughes Medical Institute, Washington University School of Medicine, 660 S. Euclid Avenue, St Louis, Missouri 63110, USA)

Abstract

L-Myc, a paralogue of the proto-oncogene c-Myc, is shown to regulate dendritic cell homeostasis and functionality; unlike c-Myc, L-Myc is not repressed by interferons and its expression allows for optimal dendritic cell proliferation and T-cell priming in the presence of inflammation.

Suggested Citation

  • Wumesh KC & Ansuman T. Satpathy & Aaron S. Rapaport & Carlos G. Briseño & Xiaodi Wu & Jörn C. Albring & Emilie V. Russler-Germain & Nicole M. Kretzer & Vivek Durai & Stephen P. Persaud & Brian T. Edel, 2014. "L-Myc expression by dendritic cells is required for optimal T-cell priming," Nature, Nature, vol. 507(7491), pages 243-247, March.
    • Handle: RePEc:nat:nature:v:507:y:2014:i:7491:d:10.1038_nature12967
    DOI: 10.1038/nature12967
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