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A transcriptional switch underlies commitment to sexual development in malaria parasites

Author

Listed:
  • Björn F. C. Kafsack

    (Lewis-Sigler Institute for Integrative Genomics, Princeton University
    Present addresses: Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA (B.F.C.K.); Department of Molecular Biology and Center for Infectious Disease Dynamics, The Pennsylvania State University, State College, Pennsylvania 16802, USA (V.M.C., M.L.).)

  • Núria Rovira-Graells

    (Barcelona Centre for International Health Research (CRESIB, Hospital Clínic-Universitat de Barcelona), Barcelona, 08036 Catalonia, Spain
    Institute for Research in Biomedicine (IRB), Barcelona, 08028 Catalonia, Spain)

  • Taane G. Clark

    (Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London WC1E 7HT, UK
    Faculty of Epidemiology and Population Health, London School of Hygiene & Tropical Medicine, London WC1E 7HT, UK)

  • Cristina Bancells

    (Barcelona Centre for International Health Research (CRESIB, Hospital Clínic-Universitat de Barcelona), Barcelona, 08036 Catalonia, Spain)

  • Valerie M. Crowley

    (Lewis-Sigler Institute for Integrative Genomics, Princeton University
    Institute for Research in Biomedicine (IRB), Barcelona, 08028 Catalonia, Spain
    Present addresses: Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA (B.F.C.K.); Department of Molecular Biology and Center for Infectious Disease Dynamics, The Pennsylvania State University, State College, Pennsylvania 16802, USA (V.M.C., M.L.).)

  • Susana G. Campino

    (Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton CB10 1SA, UK)

  • April E. Williams

    (Princeton University)

  • Laura G. Drought

    (Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London WC1E 7HT, UK)

  • Dominic P. Kwiatkowski

    (Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton CB10 1SA, UK
    Wellcome Trust Sanger Centre for Human Genetics, Oxford OX3 7BN, UK)

  • David A. Baker

    (Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London WC1E 7HT, UK)

  • Alfred Cortés

    (Barcelona Centre for International Health Research (CRESIB, Hospital Clínic-Universitat de Barcelona), Barcelona, 08036 Catalonia, Spain
    Institute for Research in Biomedicine (IRB), Barcelona, 08028 Catalonia, Spain
    Catalan Institution for Research and Advanced Studies (ICREA), Barcelona, 08010 Catalonia, Spain)

  • Manuel Llinás

    (Lewis-Sigler Institute for Integrative Genomics, Princeton University
    Princeton University
    Present addresses: Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA (B.F.C.K.); Department of Molecular Biology and Center for Infectious Disease Dynamics, The Pennsylvania State University, State College, Pennsylvania 16802, USA (V.M.C., M.L.).)

Abstract

The DNA-binding protein PfAP2-G is found to be a master regulator of sexual development in the malaria parasite; this protein appears to regulate early gametocytogenesis and is epigenetically silenced in the majority of blood-stage parasites.

Suggested Citation

  • Björn F. C. Kafsack & Núria Rovira-Graells & Taane G. Clark & Cristina Bancells & Valerie M. Crowley & Susana G. Campino & April E. Williams & Laura G. Drought & Dominic P. Kwiatkowski & David A. Bake, 2014. "A transcriptional switch underlies commitment to sexual development in malaria parasites," Nature, Nature, vol. 507(7491), pages 248-252, March.
    • Handle: RePEc:nat:nature:v:507:y:2014:i:7491:d:10.1038_nature12920
    DOI: 10.1038/nature12920
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    Cited by:

    1. Irene Otero-Muras & Pencho Yordanov & Joerg Stelling, 2017. "Chemical Reaction Network Theory elucidates sources of multistability in interferon signaling," PLOS Computational Biology, Public Library of Science, vol. 13(4), pages 1-28, April.

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