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Ultraviolet-radiation-induced inflammation promotes angiotropism and metastasis in melanoma

Author

Listed:
  • Tobias Bald

    (Laboratory of Experimental Dermatology, University of Bonn, 53115 Bonn, Germany)

  • Thomas Quast

    (Molecular Immunology and Cell Biology, Life and Medical Sciences Institute, University of Bonn, 53115 Bonn, Germany)

  • Jennifer Landsberg

    (Laboratory of Experimental Dermatology, University of Bonn, 53115 Bonn, Germany)

  • Meri Rogava

    (Laboratory of Experimental Dermatology, University of Bonn, 53115 Bonn, Germany)

  • Nicole Glodde

    (Laboratory of Experimental Dermatology, University of Bonn, 53115 Bonn, Germany)

  • Dorys Lopez-Ramos

    (Laboratory of Experimental Dermatology, University of Bonn, 53115 Bonn, Germany)

  • Judith Kohlmeyer

    (Laboratory of Experimental Dermatology, University of Bonn, 53115 Bonn, Germany)

  • Stefanie Riesenberg

    (Unit for RNA Biology, University of Bonn, 53105 Bonn, Germany)

  • Debby van den Boorn-Konijnenberg

    (Unit for RNA Biology, University of Bonn, 53105 Bonn, Germany)

  • Cornelia Hömig-Hölzel

    (Unit for RNA Biology, University of Bonn, 53105 Bonn, Germany)

  • Raphael Reuten

    (Institute for Dental Research and Oral Musculoskeletal Biology, Center for Biochemistry, Medical Faculty, University of Cologne, D-50931 Cologne, Germany)

  • Benjamin Schadow

    (Immunology and Environment, Life and Medical Sciences Institute, University of Bonn, 53115 Bonn, Germany)

  • Heike Weighardt

    (Immunology and Environment, Life and Medical Sciences Institute, University of Bonn, 53115 Bonn, Germany)

  • Daniela Wenzel

    (Institute for Physiology I, Life & Brain Center, University of Bonn, 53105 Bonn, Germany)

  • Iris Helfrich

    (University Hospital Essen, 45122 Essen, Germany)

  • Dirk Schadendorf

    (University Hospital Essen, 45122 Essen, Germany)

  • Wilhelm Bloch

    (Institute of Cardiovascular Research and Sport Medicine, German Sport University Cologne, 50933 Cologne, Germany)

  • Marco E. Bianchi

    (San Raffaele University and Scientific Institute, 20132 Milan, Italy)

  • Claire Lugassy

    (Jonsson Comprehensive Cancer Center, University of California Los Angeles (UCLA) Medical Center)

  • Raymond L. Barnhill

    (Jonsson Comprehensive Cancer Center, University of California Los Angeles (UCLA) Medical Center)

  • Manuel Koch

    (Institute for Dental Research and Oral Musculoskeletal Biology, Center for Biochemistry, Medical Faculty, University of Cologne, D-50931 Cologne, Germany)

  • Bernd K. Fleischmann

    (Institute for Physiology I, Life & Brain Center, University of Bonn, 53105 Bonn, Germany)

  • Irmgard Förster

    (Immunology and Environment, Life and Medical Sciences Institute, University of Bonn, 53115 Bonn, Germany)

  • Wolfgang Kastenmüller

    (Institutes of Molecular Medicine and Experimental Immunology, University of Bonn, 53105 Bonn, Germany)

  • Waldemar Kolanus

    (Molecular Immunology and Cell Biology, Life and Medical Sciences Institute, University of Bonn, 53115 Bonn, Germany)

  • Michael Hölzel

    (Unit for RNA Biology, University of Bonn, 53105 Bonn, Germany)

  • Evelyn Gaffal

    (Laboratory of Experimental Dermatology, University of Bonn, 53115 Bonn, Germany)

  • Thomas Tüting

    (Laboratory of Experimental Dermatology, University of Bonn, 53115 Bonn, Germany)

Abstract

Mouse experiments show that ultraviolet radiation can promote tumour metastasis in melanoma by enhancing the expansion of tumour cells on blood vessel surfaces in a process linked to inflammation and requiring neutrophils and the proteins HMGB1 and TLR4.

Suggested Citation

  • Tobias Bald & Thomas Quast & Jennifer Landsberg & Meri Rogava & Nicole Glodde & Dorys Lopez-Ramos & Judith Kohlmeyer & Stefanie Riesenberg & Debby van den Boorn-Konijnenberg & Cornelia Hömig-Hölzel & , 2014. "Ultraviolet-radiation-induced inflammation promotes angiotropism and metastasis in melanoma," Nature, Nature, vol. 507(7490), pages 109-113, March.
    • Handle: RePEc:nat:nature:v:507:y:2014:i:7490:d:10.1038_nature13111
    DOI: 10.1038/nature13111
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