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Citrullination regulates pluripotency and histone H1 binding to chromatin

Author

Listed:
  • Maria A. Christophorou

    (The Gurdon Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK)

  • Gonçalo Castelo-Branco

    (The Gurdon Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK
    Laboratory of Molecular Neurobiology, Karolinska Institutet, SE-17177 Stockholm, Sweden)

  • Richard P. Halley-Stott

    (The Gurdon Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK
    University of Cambridge, Downing Street, Cambridge CB2 3EJ, UK)

  • Clara Slade Oliveira

    (The Gurdon Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK
    EMBRAPA Dairy Cattle Research Center, Juiz de Fora, Brazil
    Development and Neuroscience, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK)

  • Remco Loos

    (European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SD, UK)

  • Aliaksandra Radzisheuskaya

    (Wellcome Trust—Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK
    University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK)

  • Kerri A. Mowen

    (The Scripps Research Institute)

  • Paul Bertone

    (European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SD, UK
    Wellcome Trust—Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK
    Genome Biology and Developmental Biology Units, European Molecular Biology Laboratory, Meyerhofstraße 1, 69117 Heidelberg, Germany)

  • José C. R. Silva

    (Wellcome Trust—Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK
    University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK)

  • Magdalena Zernicka-Goetz

    (The Gurdon Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK
    Development and Neuroscience, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK)

  • Michael L. Nielsen

    (The Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, Faculty of Health Sciences, Blegdamsvej 3b, DK-2200 Copenhagen, Denmark)

  • John B. Gurdon

    (The Gurdon Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK
    University of Cambridge, Downing Street, Cambridge CB2 3EJ, UK)

  • Tony Kouzarides

    (The Gurdon Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK
    University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK)

Abstract

This study shows that PADI4-mediated citrullination occurs during pluripotency and that citrullination of H1 results in loosening of chromatin compaction; furthermore, citrullination is shown to be important for the activation of stem-cell genes, for iPS cell reprogramming and to maintain pluripotent cells in the early mouse embryo.

Suggested Citation

  • Maria A. Christophorou & Gonçalo Castelo-Branco & Richard P. Halley-Stott & Clara Slade Oliveira & Remco Loos & Aliaksandra Radzisheuskaya & Kerri A. Mowen & Paul Bertone & José C. R. Silva & Magdalen, 2014. "Citrullination regulates pluripotency and histone H1 binding to chromatin," Nature, Nature, vol. 507(7490), pages 104-108, March.
    • Handle: RePEc:nat:nature:v:507:y:2014:i:7490:d:10.1038_nature12942
    DOI: 10.1038/nature12942
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    Cited by:

    1. Rui Chen & Zhiyuan Lin & Shengqi Shen & Chuxu Zhu & Kai Yan & Caixia Suo & Rui Liu & Haoran Wei & Li Gao & Kaixiang Fan & Huafeng Zhang & Linchong Sun & Ping Gao, 2024. "Citrullination modulation stabilizes HIF-1α to promote tumour progression," Nature Communications, Nature, vol. 15(1), pages 1-15, December.

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