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Cell-autonomous correction of ring chromosomes in human induced pluripotent stem cells

Author

Listed:
  • Marina Bershteyn

    (University of California, San Francisco
    Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco)

  • Yohei Hayashi

    (Gladstone Institute of Cardiovascular Disease, San Francisco
    Roddenberry Center for Stem Cell Biology and Medicine at Gladstone)

  • Guillaume Desachy

    (Institute for Human Genetics, University of California, San Francisco)

  • Edward C. Hsiao

    (University of California, San Francisco)

  • Salma Sami

    (Gladstone Institute of Cardiovascular Disease, San Francisco
    Roddenberry Center for Stem Cell Biology and Medicine at Gladstone)

  • Kathryn M. Tsang

    (Institute for Human Genetics, University of California, San Francisco)

  • Lauren A. Weiss

    (Institute for Human Genetics, University of California, San Francisco)

  • Arnold R. Kriegstein

    (Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco)

  • Shinya Yamanaka

    (Gladstone Institute of Cardiovascular Disease, San Francisco
    Roddenberry Center for Stem Cell Biology and Medicine at Gladstone
    University of California, San Francisco
    Center for iPS Cell Research and Application, Kyoto University, Kyoto 606-8507, Japan)

  • Anthony Wynshaw-Boris

    (University of California, San Francisco
    Case Western Reserve University)

Abstract

Generation of human induced pluripotent stem cells from patient fibroblasts containing ring chromosomes with large deletions reveals that reprogrammed cells lose the abnormal chromosome and duplicate the wild-type homologue through compensatory uniparental disomy, suggesting that cellular reprogramming may hold potential for ‘chromosome therapy’.

Suggested Citation

  • Marina Bershteyn & Yohei Hayashi & Guillaume Desachy & Edward C. Hsiao & Salma Sami & Kathryn M. Tsang & Lauren A. Weiss & Arnold R. Kriegstein & Shinya Yamanaka & Anthony Wynshaw-Boris, 2014. "Cell-autonomous correction of ring chromosomes in human induced pluripotent stem cells," Nature, Nature, vol. 507(7490), pages 99-103, March.
    • Handle: RePEc:nat:nature:v:507:y:2014:i:7490:d:10.1038_nature12923
    DOI: 10.1038/nature12923
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