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A discrete genetic locus confers xyloglucan metabolism in select human gut Bacteroidetes

Author

Listed:
  • Johan Larsbrink

    (School of Biotechnology, Royal Institute of Technology (KTH), AlbaNova University Centre, 106 91 Stockholm, Sweden)

  • Theresa E. Rogers

    (University of Michigan Medical School)

  • Glyn R. Hemsworth

    (Structural Biology Laboratory, University of York, York YO10 5DD, UK)

  • Lauren S. McKee

    (School of Biotechnology, Royal Institute of Technology (KTH), AlbaNova University Centre, 106 91 Stockholm, Sweden
    Wallenberg Wood Science Center, Royal Institute of Technology (KTH), Teknikringen 56-58, 100 44 Stockholm, Sweden)

  • Alexandra S. Tauzin

    (University of British Columbia, 2185 East Mall, Vancouver, British Columbia V6T 1Z4, Canada)

  • Oliver Spadiut

    (School of Biotechnology, Royal Institute of Technology (KTH), AlbaNova University Centre, 106 91 Stockholm, Sweden
    Wallenberg Wood Science Center, Royal Institute of Technology (KTH), Teknikringen 56-58, 100 44 Stockholm, Sweden)

  • Stefan Klinter

    (School of Biotechnology, Royal Institute of Technology (KTH), AlbaNova University Centre, 106 91 Stockholm, Sweden)

  • Nicholas A. Pudlo

    (University of Michigan Medical School)

  • Karthik Urs

    (University of Michigan Medical School)

  • Nicole M. Koropatkin

    (University of Michigan Medical School)

  • A. Louise Creagh

    (University of British Columbia, 2185 East Mall, Vancouver, British Columbia V6T 1Z4, Canada)

  • Charles A. Haynes

    (University of British Columbia, 2185 East Mall, Vancouver, British Columbia V6T 1Z4, Canada)

  • Amelia G. Kelly

    (University of Michigan Medical School)

  • Stefan Nilsson Cederholm

    (School of Biotechnology, Royal Institute of Technology (KTH), AlbaNova University Centre, 106 91 Stockholm, Sweden)

  • Gideon J. Davies

    (Structural Biology Laboratory, University of York, York YO10 5DD, UK)

  • Eric C. Martens

    (University of Michigan Medical School)

  • Harry Brumer

    (School of Biotechnology, Royal Institute of Technology (KTH), AlbaNova University Centre, 106 91 Stockholm, Sweden
    University of British Columbia, 2185 East Mall, Vancouver, British Columbia V6T 1Z4, Canada)

Abstract

A genetic locus from the gut symbiont Bacteroides ovatus is identified and described that encodes a cohort of enzymes and carbohydrate-binding proteins necessary for the metabolism of xyloglucans—a predominant component of dietary fibre.

Suggested Citation

  • Johan Larsbrink & Theresa E. Rogers & Glyn R. Hemsworth & Lauren S. McKee & Alexandra S. Tauzin & Oliver Spadiut & Stefan Klinter & Nicholas A. Pudlo & Karthik Urs & Nicole M. Koropatkin & A. Louise C, 2014. "A discrete genetic locus confers xyloglucan metabolism in select human gut Bacteroidetes," Nature, Nature, vol. 506(7489), pages 498-502, February.
    • Handle: RePEc:nat:nature:v:506:y:2014:i:7489:d:10.1038_nature12907
    DOI: 10.1038/nature12907
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    Citations

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    Cited by:

    1. Brian D. Huang & Thomas M. Groseclose & Corey J. Wilson, 2022. "Transcriptional programming in a Bacteroides consortium," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    2. Louis J. Cohen & Sun M. Han & Pearson Lau & Daniela Guisado & Yupu Liang & Toshiki G. Nakashige & Thamina Ali & David Chiang & Adeeb Rahman & Sean F. Brady, 2022. "Unraveling function and diversity of bacterial lectins in the human microbiome," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    3. Yolanda Y. Huang & Morgan N. Price & Allison Hung & Omree Gal-Oz & Surya Tripathi & Christopher W. Smith & Davian Ho & Héloïse Carion & Adam M. Deutschbauer & Adam P. Arkin, 2024. "Barcoded overexpression screens in gut Bacteroidales identify genes with roles in carbon utilization and stress resistance," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    4. Lharbi Dridi & Fernando Altamura & Emmanuel Gonzalez & Olivia Lui & Ryszard Kubinski & Reilly Pidgeon & Adrian Montagut & Jasmine Chong & Jianguo Xia & Corinne F. Maurice & Bastien Castagner, 2023. "Identifying glycan consumers in human gut microbiota samples using metabolic labeling coupled with fluorescence-activated cell sorting," Nature Communications, Nature, vol. 14(1), pages 1-13, December.

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