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Sessile alveolar macrophages communicate with alveolar epithelium to modulate immunity

Author

Listed:
  • Kristin Westphalen

    (Lung Biology Laboratory, Allergy and Critical Care, Columbia University Medical Center)

  • Galina A. Gusarova

    (Lung Biology Laboratory, Allergy and Critical Care, Columbia University Medical Center)

  • Mohammad N. Islam

    (Lung Biology Laboratory, Allergy and Critical Care, Columbia University Medical Center)

  • Manikandan Subramanian

    (Columbia University Medical Center)

  • Taylor S. Cohen

    (Columbia University Medical Center)

  • Alice S. Prince

    (Columbia University Medical Center)

  • Jahar Bhattacharya

    (Lung Biology Laboratory, Allergy and Critical Care, Columbia University Medical Center
    College of Physicians and Surgeons, Columbia University Medical Center)

Abstract

Tissue-resident macrophages are shown to stop lipopolysaccharide-induced inflammation by spreading an anti-inflammatory calcium signal to alveolar epithelial cells through connexin-43-positive gap junction channels.

Suggested Citation

  • Kristin Westphalen & Galina A. Gusarova & Mohammad N. Islam & Manikandan Subramanian & Taylor S. Cohen & Alice S. Prince & Jahar Bhattacharya, 2014. "Sessile alveolar macrophages communicate with alveolar epithelium to modulate immunity," Nature, Nature, vol. 506(7489), pages 503-506, February.
    • Handle: RePEc:nat:nature:v:506:y:2014:i:7489:d:10.1038_nature12902
    DOI: 10.1038/nature12902
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    Cited by:

    1. Mohammad Naimul Islam & Galina A. Gusarova & Shonit R. Das & Li Li & Eiji Monma & Murari Anjaneyulu & Liberty Mthunzi & Sadiqa K. Quadri & Edward Owusu-Ansah & Sunita Bhattacharya & Jahar Bhattacharya, 2022. "The mitochondrial calcium uniporter of pulmonary type 2 cells determines severity of acute lung injury," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    2. Michal Scur & Ahmad Bakur Mahmoud & Sayanti Dey & Farah Abdalbarri & Iona Stylianides & Daniel Medina-Luna & Gayani S. Gamage & Aaron Woblistin & Alexa N. M. Wilson & Haggag S. Zein & Ashley Stueck & , 2022. "Alveolar macrophage metabolic programming via a C-type lectin receptor protects against lipo-toxicity and cell death," Nature Communications, Nature, vol. 13(1), pages 1-20, December.

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