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In situ identification of bipotent stem cells in the mammary gland

Author

Listed:
  • Anne C. Rios

    (The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia
    The University of Melbourne, Parkville, Victoria 3010, Australia)

  • Nai Yang Fu

    (The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia
    The University of Melbourne, Parkville, Victoria 3010, Australia)

  • Geoffrey J. Lindeman

    (The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia
    The University of Melbourne, Parkville, Victoria 3010, Australia
    The Royal Melbourne Hospital, Parkville, Victoria 3050, Australia)

  • Jane E. Visvader

    (The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia
    The University of Melbourne, Parkville, Victoria 3010, Australia)

Abstract

The mammary epithelium undergoes profound morphogenetic changes during development. Architecturally, it comprises two primary lineages, the inner luminal and outer myoepithelial cell layers. Two opposing concepts on the nature of mammary stem cells (MaSCs) in the postnatal gland have emerged. One model, based on classical transplantation assays, postulates that bipotent MaSCs have a key role in coordinating ductal epithelial expansion and maintenance in the adult gland, whereas the second model proposes that only unipotent MaSCs identified by lineage tracing contribute to these processes. Through clonal cell-fate mapping studies using a stochastic multicolour cre reporter combined with a new three-dimensional imaging strategy, we provide evidence for the existence of bipotent MaSCs as well as distinct long-lived progenitor cells. The cellular dynamics at different developmental stages support a model in which both stem and progenitor cells drive morphogenesis during puberty, whereas bipotent MaSCs coordinate ductal homeostasis and remodelling of the mouse adult gland.

Suggested Citation

  • Anne C. Rios & Nai Yang Fu & Geoffrey J. Lindeman & Jane E. Visvader, 2014. "In situ identification of bipotent stem cells in the mammary gland," Nature, Nature, vol. 506(7488), pages 322-327, February.
    • Handle: RePEc:nat:nature:v:506:y:2014:i:7488:d:10.1038_nature12948
    DOI: 10.1038/nature12948
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    Cited by:

    1. Zhengcheng He & Ryan Ghorayeb & Susanna Tan & Ke Chen & Amanda C. Lorentzian & Jack Bottyan & Syed Mohammed Musheer Aalam & Miguel Angel Pujana & Philipp F. Lange & Nagarajan Kannan & Connie J. Eaves , 2022. "Pathogenic BRCA1 variants disrupt PLK1-regulation of mitotic spindle orientation," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    2. Elena Spina & Julia Simundza & Angela Incassati & Anupama Chandramouli & Matthias C. Kugler & Ziyan Lin & Alireza Khodadadi-Jamayran & Christine J. Watson & Pamela Cowin, 2022. "Gpr125 is a unifying hallmark of multiple mammary progenitors coupled to tumor latency," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    3. Ingrid Paine & Arnaud Chauviere & John Landua & Amulya Sreekumar & Vittorio Cristini & Jeffrey Rosen & Michael T Lewis, 2016. "A Geometrically-Constrained Mathematical Model of Mammary Gland Ductal Elongation Reveals Novel Cellular Dynamics within the Terminal End Bud," PLOS Computational Biology, Public Library of Science, vol. 12(4), pages 1-23, April.

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