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Leukaemogenesis induced by an activating β-catenin mutation in osteoblasts

Author

Listed:
  • Aruna Kode

    (College of Physicians & Surgeons, Columbia University)

  • John S. Manavalan

    (College of Physicians & Surgeons, Columbia University)

  • Ioanna Mosialou

    (College of Physicians & Surgeons, Columbia University)

  • Govind Bhagat

    (College of Physicians & Surgeons, Columbia University)

  • Chozha V. Rathinam

    (Columbia University)

  • Na Luo

    (College of Physicians & Surgeons, Columbia University)

  • Hossein Khiabanian

    (Columbia University)

  • Albert Lee

    (Columbia University)

  • Vundavalli V. Murty

    (Columbia University)

  • Richard Friedman

    (Biomedical Informatics Shared Resource, College of Physicians & Surgeons, Columbia University)

  • Andrea Brum

    (College of Physicians & Surgeons, Columbia University
    Erasmus MC, Dr. Molewaterplein 50, NL-3015 GE Rotterdam, The Netherlands)

  • David Park

    (Memorial Sloan-Kettering Cancer Center)

  • Naomi Galili

    (Myelodysplastic Syndromes Center, Columbia University)

  • Siddhartha Mukherjee

    (Departments of Medicine Hematology & Oncology Columbia University)

  • Julie Teruya-Feldstein

    (Memorial Sloan-Kettering Cancer Center)

  • Azra Raza

    (Myelodysplastic Syndromes Center, Columbia University)

  • Raul Rabadan

    (Columbia University)

  • Ellin Berman

    (Leukemia Service, Memorial Sloan-Kettering Cancer Center)

  • Stavroula Kousteni

    (College of Physicians & Surgeons, Columbia University
    College of Physicians & Surgeons, Columbia University)

Abstract

A mouse model shows that osteoblast activating β-catenin mutations alone are sufficient to initiate the development of acute myeloid leukaemia acting through increased Notch signalling.

Suggested Citation

  • Aruna Kode & John S. Manavalan & Ioanna Mosialou & Govind Bhagat & Chozha V. Rathinam & Na Luo & Hossein Khiabanian & Albert Lee & Vundavalli V. Murty & Richard Friedman & Andrea Brum & David Park & N, 2014. "Leukaemogenesis induced by an activating β-catenin mutation in osteoblasts," Nature, Nature, vol. 506(7487), pages 240-244, February.
    • Handle: RePEc:nat:nature:v:506:y:2014:i:7487:d:10.1038_nature12883
    DOI: 10.1038/nature12883
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